1-(2,4-dihydroxy-3,6-dimethylphenyl)propan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2,4-dihydroxy-3,6-dimethylphenyl)propan-1-one
• 英文别名: 1-propionyl-2,4-dihydroxy-3,6-dimethylbenzene；1-(2,4-Dihydroxy-3,6-dimethylphenyl)propan-1-one
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: UCLGNMARSVJELC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,5-二甲基间苯二酚 、 丙酸酐 在 三氟化硼乙醚 作用下， 反应 6.0h， 以100%的产率得到1-(2,4-dihydroxy-3,6-dimethylphenyl)propan-1-one
  参考文献：
  名称：

  CHROMONE DERIVATIVE HAVING OSTEOGENESIS PROMOTING EFFECT

  摘要：

  用于促进骨生成、改善骨代谢、预防或治疗骨折、预防或治疗与骨代谢相关的疾病，或在骨科领域促进骨折、骨缺损和骨关节炎等骨疾病的愈合，以及在牙科领域用于治疗牙周病和稳定人工牙根的化合物或其药理学可接受的盐。这些化合物由式(I)或其药理学可接受的盐表示：

  公开号：

  US20140349991A1

文献信息

• Kinetic characterisation of the FAD dependent monooxygenase TropB and investigation of its biotransformation potential
  作者：Amira Abood、Ahmed Al-Fahad、Alan Scott、Alaa El-Dein M. S. Hosny、Amal M. Hashem、Azza M. A. Fattah、Paul R. Race、Thomas J. Simpson、Russell J. Cox

  DOI：10.1039/c5ra06693j

  日期：——

  Achieving regio-specific hydroxylation of aromatic compounds remains a major challenge in synthetic chemistry.

  在合成化学中，实现芳香化合物的区域特异性羟基化仍然是一个重大挑战。
• Chromone derivative having osteogenesis promoting effect
  申请人：Daiichi Sankyo Company, Limited

  公开号：US09221811B2

  公开（公告）日：2015-12-29

  Compounds or pharmacologically acceptable salts thereof for promoting osteogenesis, improving bone metabolism, preventing or treating bone fracture, preventing or treating a disease associated with bone metabolism, or in the field of orthopedics for the promotion of healing of bone fracture, a bone defect, and bone diseases such as osteoarthritis as well as in the field of dentistry for the treatment of periodontal disease and the stabilization of artificial tooth root. The compounds are represented by formula (I) or a pharmacologically acceptable salt thereof:

  化合物或其药理学上可接受的盐，用于促进骨生成，改善骨代谢，预防或治疗骨折，预防或治疗与骨代谢有关的疾病，或在骨科领域促进骨折，骨缺陷和骨关节炎等骨疾病的愈合，以及在牙科领域用于治疗牙周病和稳定人工牙根。化合物由公式（I）或其药理学上可接受的盐表示：
• US9221811B2
  申请人：——

  公开号：US9221811B2

  公开（公告）日：2015-12-29
• CHROMONE DERIVATIVE HAVING OSTEOGENESIS PROMOTING EFFECT
  申请人：DAIICHI SANKYO COMPANY, LIMITED

  公开号：US20140349991A1

  公开（公告）日：2014-11-27

  Compounds or pharmacologically acceptable salts thereof for promoting osteogenesis, improving bone metabolism, preventing or treating bone fracture, preventing or treating a disease associated with bone metabolism, or in the field of orthopedics for the promotion of healing of bone fracture, a bone defect, and bone diseases such as osteoarthritis as well as in the field of dentistry for the treatment of periodontal disease and the stabilization of artificial tooth root. The compounds are represented by formula (I) or a pharmacologically acceptable salt thereof:

  用于促进骨生成、改善骨代谢、预防或治疗骨折、预防或治疗与骨代谢相关的疾病，或在骨科领域促进骨折、骨缺损和骨关节炎等骨疾病的愈合，以及在牙科领域用于治疗牙周病和稳定人工牙根的化合物或其药理学可接受的盐。这些化合物由式(I)或其药理学可接受的盐表示：