NSC 13378

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: NSC 13378
• 英文别名: (6-methoxy-[8]quinolyl)-(2-[2]piperidyl-ethyl)-amine；(6-Methoxy-[8]chinolyl)-(2-[2]piperidyl-aethyl)-amin；6-methoxy-N-(2-(2-piperidinyl)ethyl)-8-quinolinamine；6-methoxy-N-(2-piperidin-2-ylethyl)quinolin-8-amine
• 化学式: C₁₇H₂₃N₃O
• 分子量: 285.389
• InChiKey: VEVGNPJKXAYEMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  8-氨基-6-甲氧基喹啉 、 alkaline earth salt of/the/ methylsulfuric acid 生成 NSC 13378
  参考文献：
  名称：

  The Synthesis of Some Substituted 8-Aminoquinolines¹

  摘要：

  DOI：

  10.1021/ja01212a058

文献信息

• Compounds for the treatment of acute organ injury
  申请人：UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US11534425B2

  公开（公告）日：2022-12-27

  Disclosed herein are novel compounds and methods for the treatment of acute organ injury, including injuries resulting from ischemic events. The compounds may be used to treat organ including the brain, heart, or kidney, which have injured as a result of events such as stroke, cardiac arrest, traumatic brain injury, hemorrhagic shock, or subarachnoid hemorrhage.

  本文公开了用于治疗急性器官损伤（包括缺血事件导致的损伤）的新型化合物和方法。 这些化合物可用于治疗因中风、心脏骤停、脑外伤、失血性休克或蛛网膜下腔出血等事件而受伤的器官，包括大脑、心脏或肾脏。
• Protein tyrosine phosphatase-prl-1 a a marker and therapeutic target for pancreatic cancer
  申请人：Farnsworth L Amanda

  公开号：US20070026398A1

  公开（公告）日：2007-02-01

  Using gene expression profiling, the present Invention identifies Protein tyrosine phosphatase IVA member 1 (PRL-1) as a diagnostic marker and therapeutic target for pancreatic cancer. The Invention therefore provides methods for prediction and detection of PRL-1 associated cancers, and evaluation of inhibitors of PRL-1. The Invention also provides a method of treating or preventing pancreatic cancer in a subject.
• The Synthesis of Some Substituted 8-Aminoquinolines¹
  作者：T. R. Norton、R. A. Seibert、A. A. Benson、F. W. Bergstrom

  DOI：10.1021/ja01212a058

  日期：1946.8