1-(1,1,3-trihydroperfluoropropoxy)butane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(1,1,3-trihydroperfluoropropoxy)butane
• 英文别名: 1,1,3-trihydroperfluoropropoxybutane；1-(2,2,3,3-tetrafluoropropyloxy)butane；3-Butoxy-1,1,2,2-tetrafluoropropane；1-(2,2,3,3-tetrafluoropropoxy)butane
• 化学式: C₇H₁₂F₄O
• 分子量: 188.165
• InChiKey: PJZGHFICPQQNFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对甲苯磺酸正丁酯 、 四氟丙醇 在 sodium 作用下， 以46.5%的产率得到1-(1,1,3-trihydroperfluoropropoxy)butane
  参考文献：
  名称：

  Fluoroalkyl derivatives of protected glycerol by nucleophilic substitution. Fluorine-containing amphiphilic mono- and bis-methacrylates

  摘要：

  The tosylate of protected glycerol (solketal, 4-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolane) was fluoroalkylated by a nucleophilic substitution reaction with sodium polyfluoroalkoxides. On deprotection, 3-O-fluoroalkylated glycerol was obtained which was converted to mono-and bis-methacrylates; analogous methacrylate derivatives were prepared from 3,3,4,5,5,5-hexafluoro-pentane-1,2-diol. (C) 1997 Elsevier Science S.A.

  DOI：

  10.1016/s0022-1139(97)00063-8

文献信息

• Synthesis of polyfluoroalkyl chlorosulfites and new polyfluoroalkylation reactions with their participation
  作者：A. I. Rakhimov

  DOI：10.1134/s107036321008013x

  日期：2010.8

  were revealed of polyfluoroalkyl chlorosulfites synthesis by reaction of thionyl chloride with associates polyflorinated alcohol-triethylamine and of a new reaction with polyfluorinated alcohols (catalysis by amides), resulting in symmetrical simple polyfluoroalkyl ethers. New polyfluoroalkylation reactions of aliphatic (including polyfluorinated) alicyclic, benzyl alcohols, phenol, carboxylic acids and

  揭示了通过亚硫酰氯与多聚氟化醇-三乙胺缔合反应合成多氟烷基氯亚硫酸盐的规律，以及与多氟化醇的新反应（酰胺催化）的规律性，从而得到对称的简单多氟烷基醚。研究了脂肪族（包括多氟化）脂环族，苄醇，苯酚，羧酸及其盐与多氟烷基氯亚硫酸盐的新的多氟烷基化反应，该反应通过用卤素，烷氧基（或多氟烷氧基），苯氧基和酰氧基取代氯硅烷基部分来进行。开发了具有新特性的新型合成材料，用于合成高分子材料。
• Synthesis of Polyfluorinated Ethers
  作者：D. N. Bazhin、T. I. Gorbunova、A. Ya. Zapevalov、V. I. Saloutin

  DOI：10.1007/s11167-005-0578-3

  日期：2005.10

  Procedures for preparing polyfluorinated ethers H(CF2CF2) n CH2OR by alkylation of the corresponding telomeric alcohols H(CF2CF2) n CH2OH (n = 1–3) with alkyl halides and alkyl tosylates were examined.

  研究了通过与烷基卤化物和烷基托磺酸酯进行烷基化反应，制备多氟化醚 H(CF2CF2) n CH2OR（n = 1–3）的相应聚合醇 H(CF2CF2) n CH2OH 的程序。
• Features of catalysis in the reaction of polyfluoroalkyl chlorosulfites with saturated monohydric alcohols
  作者：A. I. Rakhimov、A. V. Nalesnaya、R. V. Fisechko

  DOI：10.1134/s1070363208110169

  日期：2008.11

  Synthetic opportunities and mechanism of catalysis of the reaction of polyfluororalkylchlorosulfites with saturated monohydric alcohols are considered. Kinetic measurements and quantum-chemical calculations showed that polyfluoroalkylation of these compounds proceeded through the step of complex formation involving reagents and catalyst followed by liberation of hydrogen chloride and sulfur dioxide and formation of polyfluoroalkyl ethers.
• A New Method for Preparing Polyfluorinated Ethers
  作者：A. I. Rakhimov、A. V. Nalesnaya、O. V. Vostrikova

  DOI：10.1023/b:rugc.0000031872.61546.f6

  日期：2004.4
• AZOLE COMPOUNDS WITH ANTIMYCOTIC ACTIVITY FOR HUMAN AND VETERINARY USE
  申请人：ZAMBON GROUP S.p.A.

  公开号：EP0819124A1

  公开（公告）日：1998-01-21