2'-O-[(N-phthalimido)prop-3-yl]-adenosine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2'-O-[(N-phthalimido)prop-3-yl]-adenosine
• 英文别名: 2'-O-[(N-phthalimido)prop-3-yl]adenosine；2-[1-[(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]oxypropyl]isoindole-1,3-dione
• 化学式: C₂₁H₂₂N₆O₆
• 分子量: 454.442
• InChiKey: WSSFCNJHGMCPPN-LMDXUXIUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  166
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  N-(3-溴丙基)苯二胺 生成 2'-O-[(N-phthalimido)prop-3-yl]-adenosine
  参考文献：
  名称：

  2'-modified oligonucleotides

  摘要：

  提供了用于治疗和诊断易于调节选定蛋白质产生的疾病的组合物和方法。根据首选实施方式，提供了可以与RNA或DNA的选定序列特异杂交的寡核苷酸和寡核苷酸类似物，其中核苷酸单元中的至少一个2'-脱氧呋喃糖基被修改。提供了治疗由各种病毒和其他致病因子引起的疾病的方法。

  公开号：

  US05859221A1

文献信息

• 2'modified oligonucleotides
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US06531584B1

  公开（公告）日：2003-03-11

  Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

  提供了用于治疗和诊断对调节特定蛋白质产生敏感的疾病的组合物和方法。根据优选实施例，提供了可以特异性杂交于RNA或DNA的选定序列的寡核苷酸和寡核苷酸类似物，其中核苷酸单元的至少一个2'-脱氧呋喃糖苷基被修改。提供了治疗由各种病毒和其他致病因子引起的疾病的方法。
• 2'-modified oligonucleotides
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US05859221A1

  公开（公告）日：1999-01-12

  Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

  提供了用于治疗和诊断易于调节选定蛋白质产生的疾病的组合物和方法。根据首选实施方式，提供了可以与RNA或DNA的选定序列特异杂交的寡核苷酸和寡核苷酸类似物，其中核苷酸单元中的至少一个2'-脱氧呋喃糖基被修改。提供了治疗由各种病毒和其他致病因子引起的疾病的方法。
• 2' -modified oligonucleotides
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US20030187240A1

  公开（公告）日：2003-10-02

  Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

  提供了用于治疗和诊断可调节选择蛋白质生成的疾病的组合物和方法。根据优选实施例，提供了可以与RNA或DNA的选择序列特异性杂交的寡核苷酸和寡核苷酸类似物，其中核苷酸单元的至少一个2'-脱氧呋喃糖基团被修饰。提供了治疗由各种病毒和其他致病因子引起的疾病的方法。
• 2'-MODIFIED OLIGONUCLEOTIDES
  申请人：Cook Dan Phillip

  公开号：US20080032945A1

  公开（公告）日：2008-02-07

  Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

  本发明提供了用于治疗和诊断对调节所选蛋白质产生敏感的疾病的组合物和方法。根据优选实施例，提供了可以与RNA或DNA的所选序列特异性杂交的寡核苷酸和寡核苷酸类似物，其中核苷酸单元的至少一个2'-脱氧呋喃糖基团被修改。提供了治疗由各种病毒和其他致病因子引起的疾病的方法。
• 2'-Modified Oligonucleotides
  申请人：Cook Phillip Dan

  公开号：US20090198047A1

  公开（公告）日：2009-08-06

  Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

  本发明提供了用于治疗和诊断适于调节所选蛋白质产生的疾病的组合物和方法。根据优选实施例，提供了可以与RNA或DNA的选定序列特异性杂交的寡核苷酸和寡核苷酸类似物，其中核苷酸单元的至少一个2'-脱氧呋喃糖苷基团被修饰。提供了治疗由各种病毒和其他致病因子引起的疾病的方法。