N-(4-methoxyphenyl)cyclooctanamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(4-methoxyphenyl)cyclooctanamine
• 化学式: C₁₅H₂₃NO
• mdl: MFCD11120252
• 分子量: 233.354
• InChiKey: LUJFUSWGOIJLCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-硝基苯甲醚 、 环辛烷 在 air 、 过氧化二异丙苯 作用下， 反应 16.0h， 以62%的产率得到N-(4-methoxyphenyl)cyclooctanamine
  参考文献：
  名称：

  过氧化氢介导的环戊烷与硝基芳烃的胺化反应

  摘要：

  Abstractmagnified imageA direct amination of simple cycloalkanes with nitroarenes mediated by peroxides has been discovered. Various secondary arylamines were obtained efficiently from cycloalkanes. The reaction tolerates a wide range of functionalities as well as aqueous conditions. No metal was required for this novel amination reaction.

  DOI：

  10.1002/adsc.200800689

文献信息

• Rapid Microwave-Assisted Reductive Amination of Ketones with Anilines
  作者：Barry Potter、Helen Bailey、Wesley Heaton、Nigel Vicker

  DOI：10.1055/s-2006-949639

  日期：2006.9

  Using microwave technology, a new protocol has been developed that improves the reaction rate and overall efficiency of the direct reductive amination of ketones with anilines. When using sodium triacetoxyborohydride as the reducing agent, high product yields and increased reaction rates are achieved for a variety of electronically different anilines. Furthermore, we have found that this protocol can

  使用微波技术，开发了一种新方案，可提高酮与苯胺直接还原胺化的反应速率和整体效率。当使用三乙酰氧基硼氢化钠作为还原剂时，各种电子不同的苯胺都可以实现高产率和更高的反应速率。此外，我们发现该协议也可以应用于醛类。
• An Unusual Peroxide-Mediated Amination of Cycloalkanes with Nitroarenes
  作者：Guojun Deng、Wenwen Chen、Chao-Jun Li

  DOI：10.1002/adsc.200800689

  日期：2009.2

  Abstractmagnified imageA direct amination of simple cycloalkanes with nitroarenes mediated by peroxides has been discovered. Various secondary arylamines were obtained efficiently from cycloalkanes. The reaction tolerates a wide range of functionalities as well as aqueous conditions. No metal was required for this novel amination reaction.