N-methyl-2-((1-methyl-1H-pyrazol-5-yl)(thiophen-2-yl)methoxy)ethanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-methyl-2-((1-methyl-1H-pyrazol-5-yl)(thiophen-2-yl)methoxy)ethanamine
• 英文别名: (-)-2-((1-methyl-1H-pyrazole-5-yl)(thiophene-2-yl)methoxy)-N-methylethanamine；2-((1-methyl-1H-pyrazol-5-yl)(thiophen-2-yl)methoxy)-N-methylethanamine；N-methyl-2-[(2-methylpyrazol-3-yl)-thiophen-2-ylmethoxy]ethanamine
• 化学式: C₁₂H₁₇N₃OS
• 分子量: 251.352
• InChiKey: YCPXBWHXRSEHJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  67.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-methyl-2-((1-methyl-1H-pyrazol-5-yl)(thiophen-2-yl)methoxy)ethanamine 、 乙基溴苯 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 8.0h， 以55%的产率得到N-methyl-2-((1-methyl-1H-pyrazol-5-yl)(thiophen-2-yl)methoxy)-N-phenethylethanamine
  参考文献：
  名称：

  [EN] METHYL-1H-PYRAZOLE ALKYLAMINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
  [FR] COMPOSÉS MÉTHYL-1H-PYRAZOLE-ALKYLAMINES AYANT UNE ACTIVITÉ MULTIMODALE CONTRE LA DOULEUR

  摘要：

  本发明涉及具有对σ受体和μ-阿片受体具有双重药理活性的化合物，更具体地涉及具有这种药理活性的甲基-1H-吡唑烷胺化合物，以及制备这些化合物的过程，包括含有它们的药物组合物，以及它们在治疗中的用途，特别是用于疼痛治疗。

  公开号：

  WO2016096127A1

文献信息

• [EN] ARYL (OR HETEROARYL) AZOLYLCARBINOLS<br/>[FR] ARYL (OU HETEROARYL) AZOLYLCARBINOLS
  申请人：ESTEVE LABOR DR

  公开号：WO2006010627A1

  公开（公告）日：2006-02-02

  The present application provides a method of treating a subject suffering from a form of urinary incontinence which comprises administering to the subject an amount of a compound having the structure: formula (I) effective to treat the subject, wherein the compound is administered in a suitable form.

  本申请提供了一种治疗患有某种尿失禁的受试者的方法，该方法包括向受试者施用具有结构式（I）的化合物的一定量，该量足以治疗受试者，其中化合物以适当的形式施用。
• Aryl (or heteroaryl) azolylcarbinols
  申请人：Gomis Farre Antonio

  公开号：US20070021485A1

  公开（公告）日：2007-01-25

  The present application provides a method of treating a subject suffering from a form of urinary incontinence which comprises administering to the subject an amount of a compound having the structure: effective to treat the subject, wherein the compound is administered in a suitable form.

  本申请提供了一种治疗患有一种尿失禁形式的受试者的方法，该方法包括向受试者施用具有以下结构的化合物的量：有效治疗受试者，其中化合物以适当的形式施用。
• Derivatives of aryl (or heteroaryl) azolylcarbinols (in particular cizolirtin citrate) for the treatment of opioid addiction
  申请人：Laboratorios Dr. Esteve S.A.

  公开号：EP1632227A1

  公开（公告）日：2006-03-08

  The present invention refers to the use of derivatives of aryl (or heteroaryl) azolylcarbinols of general formula (I), and their physiologically acceptable salts, as medicinal products for human and/or animal therapeutics for the treatment of the symptoms of central neuropathic pain, especially certain subtypes of central neuropathic pain, as well as treatment of the disease causing the symptoms, the prevention or the prophylaxis of the symptoms of central neuropathic pain, especially certain subtypes of central neuropathic pain, as well as the prevention or the prophylaxis of the disease causing the symptoms. The preferred compound is Cizolirtin Citrate.

  本发明是指将通式（I）的芳基（或杂芳基）唑基甲醇的衍生物及其生理上可接受的盐类作为人类和/或动物治疗的药物产品，用于治疗中枢神经病理痛的症状，尤其是某些亚型的中枢神经病理痛，以及治疗引起中枢神经病理痛症状的疾病，预防中枢神经病理痛的症状，尤其是某些亚型的中枢神经病理痛、特别是某些亚型的中枢神经病理痛，以及治疗引起症状的疾病，预防中枢神经病理痛的症状，特别是某些亚型的中枢神经病理痛，以及预防引起症状的疾病。首选化合物是枸橼酸西唑利汀。
• Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of central neuropathic pain
  申请人：Laboratorios Dr. Esteve S.A.

  公开号：EP1642577A1

  公开（公告）日：2006-04-05

  The present invention refers to the use of derivatives of aryl (or heteroaryl) azolylcarbinols of general formula (I), and their physiologically acceptable salts, as medicinal products for human and/or animal therapeutics for the treatment of the symptoms of central neuropathic pain, especially certain subtypes of central neuropathic pain, as well as treatment of the disease causing the symptoms, the prevention or the prophylaxis of the symptoms of central neuropathic pain, especially certain subtypes of central neuropathic pain, as well as the prevention or the prophylaxis of the disease causing the symptoms.

  本发明是指将通式（I）的芳基（或杂芳基）唑基甲醇的衍生物及其生理上可接受的盐类作为人类和/或动物治疗的药物产品，用于治疗中枢神经病理痛的症状，尤其是某些亚型的中枢神经病理痛，以及治疗引起中枢神经病理痛症状的疾病，预防中枢神经病理痛的症状，尤其是某些亚型的中枢神经病理痛、特别是某些亚型的中枢神经病理痛，以及治疗引起症状的疾病，预防中枢神经病理痛的症状，特别是某些亚型的中枢神经病理痛，以及预防引起症状的疾病。
• Derivatives of aryl(or heteroaryl) azolycarbinols for the treatment of fibromyalgia
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1690537A1

  公开（公告）日：2006-08-16

  The present invention refers to the use of derivatives of aryl (or heteroaryl) azolylcarbinols of general formula (I), and their physiologically acceptable salts, as medicinal products for human and/or animal therapeutics for the treatment of the symptoms of fibromyalgia, the prevention or the prophylaxis of the symptoms of fibromyalgia, as well as the prevention or the prophylaxis of the disease causing the symptoms.

  本发明是指将通式（I）的芳基（或杂芳基）唑基甲醇的衍生物及其生理上可接受的盐类作为人类和/或动物治疗的药物产品，用于治疗纤维肌痛的症状，预防纤维肌痛的症状，以及预防引起症状的疾病。