ethyl 4-(p-chlorophenyl)-2-methyl-5-oxo-7-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 4-(p-chlorophenyl)-2-methyl-5-oxo-7-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
• 英文别名: ethyl 4-(4-chlorophenyl)-2-methyl-5-oxo-7-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate；ethyl 4-(4-chlorophenyl)-2-methyl-5-oxo-7-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
• 化学式: C₂₅H₂₄ClNO₃
• mdl: MFCD00614944
• 分子量: 421.923
• InChiKey: BVOJDCQQRWMACO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-phenyl-cyclohexane-1,3-dione 、 乙酰乙酸乙酯 、 4-氯苯甲醛 在 ammonium acetate 作用下， 以 neat (no solvent) 为溶剂， 反应 0.53h， 以92%的产率得到ethyl 4-(p-chlorophenyl)-2-methyl-5-oxo-7-phenyl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
  参考文献：
  名称：

  Nano-zirconia as an excellent nano support for immobilization of sulfonic acid: a new, efficient and highly recyclable heterogeneous solid acid nanocatalyst for multicomponent reactions

  摘要：

  报告了一种新型的、高效的、可回收的纳米催化剂——纳米氧化锆支撑的磺酸，用于合成多组分反应。

  DOI：

  10.1039/c5nj02430g

文献信息

• TiO₂-coated magnetite nanoparticle-supported sulfonic acid as a new, efficient, magnetically separable and reusable heterogeneous solid acid catalyst for multicomponent reactions
  作者：Ali Amoozadeh、Sanaz Golian、Salman Rahmani

  DOI：10.1039/c5ra06515a

  日期：——

  TiO₂-coated magnetite nanoparticles-supported sulfonic acid (nano-Fe₃O₄–TiO₂–SO₃H (n-FTSA)) is synthesized by the immobilization of –SO₃H groups on the surface of nano-Fe₃O₄–TiO₂.

  TiO₂涂覆的磁铁矿纳米颗粒支撑磺酸（纳米Fe₃O₄–TiO₂–SO₃H (n-FTSA)）是通过将-SO₃H基团固定在纳米Fe₃O₄–TiO₂表面合成的。
• A solvent-free synthesis of polyhydroquinolines via Hantzsch multicomponent condensation catalyzed by nanomagnetic-supported sulfonic acid
  作者：Somayeh Otokesh、Nadiya Koukabi、Eskandar Kolvari、Ali Amoozadeh、Masoumeh Malmir、Saeede Azhar

  DOI：10.17159/0379-4350/2015/v68a3

  日期：——

  procedure for the synthesis of polyhydroquinolines was developed, involving a one-pot four-component Hantzsch condensation of aromatic aldehydes, 1,3-cyclohexanediones, alkyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanomagnetic-supported sulfonic acid under solvent-free conditions. The method offers several advantages including high yields, short reaction times, a simple

  开发了一种简单有效的合成聚氢喹啉的方法，该方法涉及在催化量的纳米磁性负载的磺酸存在下，一锅四组分芳香醛，1,3-环己二酮，乙酰乙酸烷基酯和乙酸铵的Hantzsch缩合反应。无溶剂条件下的酸。该方法具有几个优点，包括高产率，短反应时间，简单的后处理程序和催化剂在多次运行中的可重复使用性。此外，通过使用外部磁体，能够容易地从反应混合物中分离出催化剂。
• Nano-zirconia as an excellent nano support for immobilization of sulfonic acid: a new, efficient and highly recyclable heterogeneous solid acid nanocatalyst for multicomponent reactions
  作者：Ali Amoozadeh、Salman Rahmani、Mehrnoosh Bitaraf、Fatemeh Bolghan Abadi、Elham Tabrizian

  DOI：10.1039/c5nj02430g

  日期：——

  Nano-zirconia-supported sulfonic acid as a novel, highly efficient and recyclable heterogeneous nanocatalyst is reported for the synthesis of multicomponent reactions.

  报告了一种新型的、高效的、可回收的纳米催化剂——纳米氧化锆支撑的磺酸，用于合成多组分反应。