2-(4'-methoxyphenyl)-4-methylphenylethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4'-methoxyphenyl)-4-methylphenylethanone
• 英文别名: 1-[2-(4-Methoxyphenyl)-4-methylphenyl]ethanone；1-[2-(4-methoxyphenyl)-4-methylphenyl]ethanone
• 化学式: C₁₆H₁₆O₂
• 分子量: 240.302
• InChiKey: UJBGIDPJVPSQLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氯苯甲醚 、 4-methoxy-N-(1-p-tolylethyliden)aniline 在 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 3 A molecular sieve 、 potassium carbonate 、 di-1-adamantylphosphine oxide 、 盐酸 作用下， 以 N-甲基吡咯烷酮 、 乙醚 为溶剂， 反应 21.0h， 以77%的产率得到2-(4'-methoxyphenyl)-4-methylphenylethanone
  参考文献：
  名称：

  Phosphine Oxides as Preligands in Ruthenium-Catalyzed Arylations via C−H Bond Functionalization Using Aryl Chlorides

  摘要：

  The use of air-stable, electron-rich phosphine oxides as preligands allows for unprecedented general ruthenium-catalyzed arylation reactions of pyridines and imines through C-H-bond activation using aryl chlorides. The catalytic system derived from a sterically hindered adamantyl-substituted phosphine oxide proves highly efficient and tolerates a number of important functional groups.

  DOI：

  10.1021/ol051216e

文献信息

• Phosphine Oxides as Preligands in Ruthenium-Catalyzed Arylations via C−H Bond Functionalization Using Aryl Chlorides
  作者：Lutz Ackermann

  DOI：10.1021/ol051216e

  日期：2005.7.1

  The use of air-stable, electron-rich phosphine oxides as preligands allows for unprecedented general ruthenium-catalyzed arylation reactions of pyridines and imines through C-H-bond activation using aryl chlorides. The catalytic system derived from a sterically hindered adamantyl-substituted phosphine oxide proves highly efficient and tolerates a number of important functional groups.