5-methyl-2-phenyloxazole-4-carboxylic acid diethylamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-methyl-2-phenyloxazole-4-carboxylic acid diethylamide
• 英文别名: N,N-diethyl-5-methyl-2-phenyl-1,3-oxazole-4-carboxamide
• 化学式: C₁₅H₁₈N₂O₂
• 分子量: 258.32
• InChiKey: GVTZCRSPKQVUTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N,N-二乙基乙酰乙酰胺 、 苄胺 在 碘化铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以67%的产率得到5-methyl-2-phenyloxazole-4-carboxylic acid diethylamide
  参考文献：
  名称：

  在温和条件下用电化学方法促进β-二酮衍生物和苄胺合成多取代的恶唑†

  摘要：

  描述了由容易获得的β-二酮衍生物和苄胺有效地电化学合成多取代的恶唑的方法。该电化学程序不需要有害的氧化剂和过渡金属催化剂以及分子I 2添加剂。与传统的热化学方法相比，本发明的电化学方法更绿色，更有效。

  DOI：

  10.1039/c4ra03865g

文献信息

• Preparation of New Microgel Polymers and Their Application as Supports in Organic Synthesis
  作者：Carsten Spanka、Bruce Clapham、Kim D. Janda

  DOI：10.1021/jo016362m

  日期：2002.5.1

  A series of soluble microgel polymers have been synthesized using solution-phase polymerization reactions. In a systematic manner, several variables such as monomer concentration, cross-linker content, reaction solvent and reaction time were examined, and this provided an optimal polymer with both solubility and precipitation characteristics suitable for synthetic applications. Thus, a chemically functionalized microgel polymer was synthesized, and the utility of this polymer in the synthesis of a small array of oxazole compounds has been demonstrated. The advantage of the microgel polymers produced was that they exhibited solution viscosities lower than those of conventional linear polymers even at higher concentrations, and this was found to be beneficial for their precipitation properties. Compounds prepared using the described microgel polymer supports were obtained in similar yields and purity when compared with insoluble resins, and more importantly, the soluble polymer bound intermediates could be analyzed at each step using standard NMR techniques.
• Electrochemically promoted synthesis of polysubstituted oxazoles from β-diketone derivatives and benzylamines under mild conditions
  作者：Gaoqing Yuan、Zechen Zhu、Xiaofang Gao、Huanfeng Jiang

  DOI：10.1039/c4ra03865g

  日期：——

  An efficient electrochemical synthesis of poly-substituted oxazoles from readily available β-diketone derivatives and benzylamines is described. This electrochemical procedure does not need hazardous oxidants and transition metal catalysts as well as molecular I2 additives. Compared with the traditional thermo-chemical method, the present electrochemical method is greener and more efficient.

  描述了由容易获得的β-二酮衍生物和苄胺有效地电化学合成多取代的恶唑的方法。该电化学程序不需要有害的氧化剂和过渡金属催化剂以及分子I 2添加剂。与传统的热化学方法相比，本发明的电化学方法更绿色，更有效。