7-chloropyrrolo[1,2-a]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-chloropyrrolo[1,2-a]quinoline
• 英文别名: 7-Chloropyrrolo[1,2-a]quinoline
• 化学式: C₁₂H₈ClN
• 分子量: 201.655
• InChiKey: TUYNDYJDIZZCNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  4.4
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  1-(4-chloro-2-oxiranylphenyl)pyrrole 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以50%的产率得到7-chloropyrrolo[1,2-a]quinoline
  参考文献：
  名称：

  A new method for the synthesis of pyrrolo[1,2-a]quinolines based on boron trifluoride-mediated cyclization of 1-(2-oxiranylphenyl)pyrroles

  摘要：

  A simple synthesis of pyrrolo[1,2-a]quinolines carrying no substituent at all of the 1- to 5-positions based on boron trifluoride-mediated cyclization of 1-(2-oxiranylphenyl)pyrroles, which can be easily prepared from 2-(pyrrol-1-yl)benzaldehydes, is described.

  DOI：

  10.1016/s0385-5414(07)81207-x

文献信息

• Palladium-Catalyzed Annulation of Aryl Heterocycles with Strained Alkenes
  作者：David G. Hulcoop、Mark Lautens

  DOI：10.1021/ol070475w

  日期：2007.4.1

  An annulation reaction proceeding by the intermolecular addition of an arylpalladium(II) halide across a strained alkene, followed by an intramolecular C-H functionalization of a pendant heterocycle is described. A variety of polycyclic heterocycles have been prepared from readily accessible haloaryl heterocycles by annulation with a range of strained alkene partners.
• A new method for the synthesis of pyrrolo[1,2-a]quinolines based on boron trifluoride-mediated cyclization of 1-(2-oxiranylphenyl)pyrroles
  作者：K KOBAYASHI、A TAKANOHASHI、Y HIMEI、T SANO、S FUKAMACHI、O MORIKAWA、H KONISHI

  DOI：10.1016/s0385-5414(07)81207-x

  日期：2007.12.1

  A simple synthesis of pyrrolo[1,2-a]quinolines carrying no substituent at all of the 1- to 5-positions based on boron trifluoride-mediated cyclization of 1-(2-oxiranylphenyl)pyrroles, which can be easily prepared from 2-(pyrrol-1-yl)benzaldehydes, is described.