4-methyl-7-methoxy-2-(4-quinolylmethylenehydrazino)quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-methyl-7-methoxy-2-(4-quinolylmethylenehydrazino)quinoline
• 英文别名: 7-methoxy-4-methyl-N-[(E)-quinolin-4-ylmethylideneamino]quinolin-2-amine
• 化学式: C₂₁H₁₈N₄O
• 分子量: 342.4
• InChiKey: BHCGCTZWUIXMKF-YDZHTSKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Methods and kits for detecting misfolded proteins
  申请人：Yale University

  公开号：US11125758B2

  公开（公告）日：2021-09-21

  Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.

  提供了与诊断、治疗和/或预防子痫前期有关的方法、试剂盒和化合物。
• Compounds and methods for diagnosing and treating amyloid-related conditions
  申请人：Pharmacia & Upjohn Company

  公开号：US20030219377A1

  公开（公告）日：2003-11-27

  The invention provides methods for diagnosing and treating amyloid-related conditions and compounds useful for the same. The invention provides for detecting, imaging, monitoring, diagnosing, and treating conditions characterized by the binding or aggregation of amyloid fibrils. More particularly, the invention relates to using quinolinehydrazone compounds for diagnosing and treating amyloidotic conditions and also as an antioxidant.

  本发明提供了诊断和治疗淀粉样蛋白相关疾病的方法以及用于诊断和治疗淀粉样蛋白相关疾病的化合物。本发明提供了检测、成像、监测、诊断和治疗以淀粉样纤维结合或聚集为特征的病症的方法。更具体地说，本发明涉及使用喹啉腙化合物诊断和治疗淀粉样变性病症，并用作抗氧化剂。
• COMPOUNDS AND METHODS FOR DIAGNOSING AND TREATING AMYLOID-RELATED CONDITIONS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1318982A1

  公开（公告）日：2003-06-18
• METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF PREECLAMPSIA
  申请人：Buhimschi Catalin S.

  公开号：US20110280863A1

  公开（公告）日：2011-11-17

  Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.
• METHODS AND KITS FOR DETECTING MISFOLDED PROTEINS
  申请人：Yale University

  公开号：US20160097775A1

  公开（公告）日：2016-04-07

  Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.