Tranilast monohydrate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Tranilast monohydrate
• 英文别名: 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid;hydrate
• 化学式: C18H19NO6
• 分子量: 345.3
• InChiKey: PYUJHFACNOHAGN-VRTOBVRTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.23
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  85.9
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Stable shaped particles of crystalline organic compounds
  申请人：Skendi Finance, Ltd.

  公开号：EP2085075A1

  公开（公告）日：2009-08-05

  The present invention provides storage stable, shaped particles of allotropic organic compounds. The particles of the present invention can be shaped according to the desired application. Preferred shapes of such particles are microspheres, particularly those having diameters of about 1 to about 1.000 microns. The stable shaped particles of the present invention are particularly well-suited to the fabrication of pharmaceutical formulations, particularly where sustained release and uniform bioavailability are desired. The storage stable particles are formed by a solid state crystallization of allotropic organic compounds. The solid state crystallization process of the present invention affords a means for achieving a storage stable crystalline form of said allotropic compound without loss or deterioration of the original particle dimensions.

  本发明提供了贮存稳定的异方性有机化合物成型颗粒。本发明的微粒可根据所需用途进行成型。此类颗粒的首选形状是微球，特别是直径约为 1 至 1.000 微米的微球。本发明的形状稳定的微粒特别适用于药物制剂的制造，尤其是在需要持续释放和均匀生物利用度的情况下。贮存稳定的颗粒是通过各向同性有机化合物的固态结晶形成的。本发明的固态结晶工艺提供了一种方法，可使所述各向同性化合物形成贮存稳定的结晶形式，而不会损失或降低原始颗粒的尺寸。
• METHOD OF PRODUCING MICROPARTICLES TO BE INGESTED INTO THE BODY, MICROPARTICLES TO BE INGESTED INTO THE BODY AND DISPERSION AND MEDICINAL COMPOSITION CONTAINING THE SAME
  申请人：M Technique Co., Ltd.

  公开号：EP2177210A1

  公开（公告）日：2010-04-21

  A method of separating biologically ingestible microparticles is used to obtain biologically ingestible microparticles in a thin film fluid formed between two processing surfaces provided with a solution containing a first solvent in which an objective substance to be pulverized is dissolved and a solvent capable of serving as a second solvent in which the solubility of the microparticles is lower than in the first solvent, the two processing surfaces being arranged so as to be able to approach to and separate from each other, at least one of which rotates relative to the other. In the method for producing biologically ingestible microparticles by separating raw materials of biologically ingestible microparticles by a neutralization reaction in a fluid, the fluid is formed into a thin film fluid between two processing surfaces arranged so as to be able to approach to and separate from each other, at least one of which rotates relative to the other, and biologically ingestible microparticles are separated by a neutralization reaction in the thin film fluid. A solution containing a first solvent in which a chemical as a main eye drop component is dissolved, and a solvent capable of serving as a second solvent in which the solubility of the chemical is lower than in the first solvent, are mixed in a thin film fluid formed between two processing surfaces arranged so as to be able to approach to and separate from each other, at least one of which rotates relative to the other, thereby separating drug particles and providing suspended eye drops based on the drug particles.

  一种分离生物可摄取微粒的方法用于在薄膜流体中获得生物可摄取微粒，薄膜流体形成于两个加工表面之间，加工表面上有溶液，溶液中含有第一种溶剂，待粉碎的目标物质溶解在第一种溶剂中，还有一种溶剂可作为第二种溶剂，微粒在第二种溶剂中的溶解度低于在第一种溶剂中的溶解度，两个加工表面布置成能够相互接近和分离，其中至少一个加工表面相对于另一个加工表面旋转。 在通过在流体中的中和反应分离生物可摄取微粒的原料来生产生物可摄取微粒的方法中，流体在两个加工表面之间形成薄膜流体，这两个加工表面的布置使其能够相互接近和分离，其中至少一个加工表面相对于另一个加工表面旋转，生物可摄取微粒通过薄膜流体中的中和反应分离。 在两个加工表面之间形成的薄膜流体中混合含有第一溶剂的溶液，第一溶剂中溶解有作为眼药水主要成分的化学物质，第二溶剂中该化学物质的溶解度低于第一溶剂中的溶解度。
• METHOD FOR PRODUCING NANOPARTICLES BY FORCED ULTRA-THIN FILM ROTARY PROCESSING
  申请人：M Technique Co., Ltd.

  公开号：EP2184109A1

  公开（公告）日：2010-05-12

  The present invention provides a method for producing nanoparticles, which comprises maintaining a minute space of 1 mm or less between two processing surfaces capable of approaching to and separating from each other and being rotating relative to each other, allowing the minute space maintained between the two processing surfaces to serve as a flow path of a processed fluid thereby forming a forced thin film of the processed fluid and separating nanoparticles in the forced thin film.

  本发明提供了一种生产纳米颗粒的方法，该方法包括在两个能够相互接近和分离并相对旋转的加工表面之间保持 1 毫米或更小的微小空间，使两个加工表面之间保持的微小空间成为加工流体的流动路径，从而形成加工流体的强制薄膜，并分离强制薄膜中的纳米颗粒。
• STABLE SHAPED PARTICLES OF CRYSTALLINE ORGANIC COMPOUNDS
  申请人：Savoir, John Claude

  公开号：EP1056444A1

  公开（公告）日：2000-12-06
• Method for effecting solid state crystallization
  申请人：Skendi Finance, Ltd.

  公开号：EP1772141B1

  公开（公告）日：2009-04-01