(E)-3-(3,4-dichlorophenyl)-N-[4-[[3-(5-hydroxy-1H-indol-3-yl)-8-azabicyclo[3.2.1]octan-8-yl]methyl]cyclohexyl]prop-2-enamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-(3,4-dichlorophenyl)-N-[4-[[3-(5-hydroxy-1H-indol-3-yl)-8-azabicyclo[3.2.1]octan-8-yl]methyl]cyclohexyl]prop-2-enamide
• 化学式: C₃₁H₃₅Cl₂N₃O₂
• 分子量: 552.5
• InChiKey: DKMPNHJOVOVCMF-UUILKARUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  68.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR DETECTING CCR2 RECEPTORS
  申请人：Liu Yongjian

  公开号：US20170348442A1

  公开（公告）日：2017-12-07

  Among the various aspects of the present disclosure is the provision of compositions of imaging agents and methods for use in detecting, monitoring, and evaluating CCR2 associated diseases, disorders, and conditions.

  本公开涉及的各个方面包括提供成像剂组合物和方法，用于检测、监测和评估与CCR2相关的疾病、障碍和病况。
• MYELOID DERIVED SUPPRESSOR CELL INHIBITING AGENTS
  申请人：Dow Steven W.

  公开号：US20120156280A1

  公开（公告）日：2012-06-21

  Myeloid derived suppressor cell (MDSC) inhibitory agents and vaccine and/or adjuvant enhancers are provided. Improved vaccine treatment regimens employing these agents are also provided. Cancer vaccines and methods for inhibiting tumor growth and cancer metastases are also presented. The myeloid derived suppressor cell (MDSC) inhibiting agents are described as bisphosphonates (such as liposomal clodronate) and CCR2 inhibitors and/or CCR2 antagonists. Methods for enhancing antibody titer levels in response to an antigen of interest are also provided.
• OPTIMIZED CANCER STEM CELL VACCINES
  申请人：COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

  公开号：US20180085445A1

  公开（公告）日：2018-03-29

  The present invention provides cancer stem cell vaccines useful for treating or preventing a variety of tumors, as well as related methods of producing cancer stem cells and antigens thereof and producing vaccine adjuvants with enhanced activity for use with the stem cell vaccines.
• METHODS FOR DETECTING CCR2 RECEPTORS
  申请人：Liu Yongjian

  公开号：US20200405889A1

  公开（公告）日：2020-12-31

  Among the various aspects of the present disclosure is the provision of compositions of imaging agents and methods for use in detecting, monitoring, and evaluating CCR2 associated diseases, disorders, and conditions.
• US9320735B2
  申请人：——

  公开号：US9320735B2

  公开（公告）日：2016-04-26