4-[(3,5-bis-trifluoromethyl-benzyl)-methoxycarbonyl-amino]-2-isopropyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-[(3,5-bis-trifluoromethyl-benzyl)-methoxycarbonyl-amino]-2-isopropyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester
• 英文别名: cis-4-[(3,5-Bis-trifluoromethyl-benzyl)-methoxycarbonyl-amino]-2-isopropyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid isopropyl ester；propan-2-yl 4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-propan-2-yl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
• 化学式: C₂₈H₂₉F₉N₂O₄
• 分子量: 628.535
• InChiKey: IMHUVAAQBSIFDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  43
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  13

文献信息

• 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
  申请人：DeNinno P. Michael

  公开号：US20050245570A1

  公开（公告）日：2005-11-03

  Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

  胆固醇酯转移蛋白抑制剂，含有这种抑制剂的药物组合物以及使用这种抑制剂提高某些血浆脂质水平，包括高密度脂蛋白胆固醇，并降低某些其他血浆脂质水平，如低密度脂蛋白胆固醇和甘油三酯，因此治疗低高密度脂蛋白胆固醇和/或高低密度脂蛋白胆固醇和甘油三酯水平加重的疾病，如动脉粥样硬化和某些哺乳动物，包括人类的心血管疾病。
• 4-protected-amino-2-substituted-1,2,3,4-tetrahydroquinolines as intermediates for CETP inhibitors
  申请人：Pfizer Products Inc.

  公开号：EP1607389A1

  公开（公告）日：2005-12-21

  The present invention relates to compounds of formula wherein P2, R2, R5, R6, R7 and R8 are as defined herein, which are useful as intermediates in the synthesis of 4-carboxyarnino-2-substitated-1,2,3,4-tetrahydroquinolines.

  本发明涉及式如下的化合物 其中 P2、R2、R5、R6、R7 和 R8 如本文所定义，可用作合成 4-羧基炔诺-2-取代基-1,2,3,4-四氢喹啉的中间体。
• 4-CARBOXYAMINO-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS
  申请人：Pfizer Products Inc.

  公开号：EP1114031B1

  公开（公告）日：2005-06-15
• PHARMACEUTICAL COMPOSITIONS OF DISPERSIONS OF DRUGS AND NEUTRAL POLYMERS
  申请人：Pfizer Products Inc.

  公开号：EP1404300A1

  公开（公告）日：2004-04-07
• PHARMACEUTICAL COMPOSITIONS OF ADSORBATES OF AMORPHOUS DRUG
  申请人：Pfizer Products Inc.

  公开号：EP1404302A1

  公开（公告）日：2004-04-07