2-Methyl-4-[4-(2-methylquinolin-4-yl)-1,4-diazepan-1-yl]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-Methyl-4-[4-(2-methylquinolin-4-yl)-1,4-diazepan-1-yl]quinoline
• 化学式: C₂₅H₂₆N₄
• 分子量: 382.5
• InChiKey: KDXKTBLLOZDBKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Spiroisoquinoline compound, a method for preparing the same and an intermediate thereof
  申请人：——

  公开号：US20040106635A1

  公开（公告）日：2004-06-03

  The present invention provides a novel spiroistiquinoline derivative of the formula [I]: which has a small-conductance potassium channel (SK) blocking activity and is useful as a medicament, a method for preparing the same and an intermediate thereof. 1

  本发明提供了一种新的螺环异喹啉衍生物，其化学式为[I]：具有小电导钾通道（SK）阻滞活性，可用作药物，提供其制备方法和中间体。1
• Pyrazolopyrimidine compound and a process for preparing the same
  申请人：Takamuro Iwao

  公开号：US20060135525A1

  公开（公告）日：2006-06-22

  The present invention provides a novel pyrazolopyrimidine compound of the formula [I]: wherein R′ is (A) a substituted aryl group, (B) an optionally substituted nitrogen-containing aliphatic heteromonocyclic group, (C) a substituted cyclo-lower alkyl group, (D) an optionally substituted amino group, or (E) a substituted heteroaryl group, R 2 is (a) an optionally substituted heteroaryl group or (b) an optionally substituted aryl group, Y is a single bond, a lower alkylene group or a lower alkenylene group, Z is a group of the formula: —CO—, —CH2-, S02- or a group of the formula [II]: Q is a lower alkylene group, and q is an integer of 0 or 1 or a pharmaceutically acceptable sait thereof, which has a small conductance potassium channel (SK channel) blocking activity and is useful as a medicament and a process for preparing the same.

  本发明提供了一种新型的吡唑嘧啶化合物，其化学式为[I]：其中R′为（A）取代芳基，（B）可选取代的含氮脂肪杂环基，（C）取代的环低烷基，（D）可选取代的氨基或（E）取代的杂环芳基；R2为（a）可选取代的杂环芳基或（b）可选取代的芳基；Y为单键，低碳基烷基或低碳基烯基；Z为式[II]的基团：其中Q为低碳基烷基，q为0或1的整数，或其药学上可接受的盐。该化合物具有小电导钾通道（SK通道）阻滞活性，并可作为药物使用，以及其制备方法。
• Nitrogenous Fused Bicyclic Compound
  申请人：Takamuro Iwao

  公开号：US20080081817A1

  公开（公告）日：2008-04-03

  A novel nitrogenous fused bicyclic compound represented by the following general formula [1] or a pharmacologically acceptable salt of the compound. They have excellent SK channel blocking activity and are useful as a medicine. [I] (In the formula, R 0 represents hydrogen, halogeno, etc.; R 1 represents a group represented by the formula (a) or (b); A represents a group represented by the formula (X) or (Y); D 1 , D 2 and D 3 each represents N or CH; R 2 represents halogeno or optionally halogenated lower alkyl, etc.; R 3 represents hydrogen or lower alkyl; and Q represents lower alkylene.)

  下面是一种新型的含氮融合双环化合物，其通式如下[1]，或其药理学上可接受的盐。它们具有出色的SK通道阻滞活性，是一种有用的药物。[I]（在公式中，R0代表氢，卤素等; R1代表由公式（a）或（b）表示的基团; A代表由公式（X）或（Y）表示的基团; D1，D2和D3分别表示N或CH; R2代表卤素或可选卤代的低碳基等; R3代表氢或低碳基; Q代表低碳链基）。
• NITROGENOUS FUSED BICYCLIC COMPOUND
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1772454A1

  公开（公告）日：2007-04-11

  A novel nitrogenous fused bicyclic compound represented by the following general formula [1] or a pharmacologically acceptable salt of the compound. They have excellent SK channel blocking activity and are useful as a medicine. [I] (In the formula, R0 represents hydrogen, halogeno, etc.; R1 represents a group represented by the formula (a) or (b); A represents a group represented by the formula (X) or (Y); D1, D2 and D3 each represents N or CH; R2 represents halogeno or optionally halogenated lower alkyl, etc.; R3 represents hydrogen or lower alkyl; and Q represents lower alkylene.)

  一种由以下通式[1]代表的新型含氮融合双环化合物或其药理学上可接受的盐。它们具有优异的 SK 通道阻断活性，可用作药物。[I]（式中，R0 代表氢、卤素等；R1 代表由式（a）或（b）表示的基团；A 代表由式（X）或（Y）表示的基团；D1、D2 和 D3 各自代表 N 或 CH；R2 代表卤素或任选卤化的低级烷基等；R3 代表氢或低级烷基；Q 代表低级亚烷基）。
• SPIROISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1373247A2

  公开（公告）日：2004-01-02