2-(4-Hydroxy-phenyl)-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinolin-6-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(4-Hydroxy-phenyl)-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinolin-6-ol
• 英文别名: 2-(4-hydroxyphenyl)-1-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-3,4-dihydro-2H-quinolin-6-ol
• 化学式: C₂₇H₃₀N₂O₃
• 分子量: 430.5
• InChiKey: OWIQDPLCVNXIEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  56.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• TETRAHYDROQUINOLIN DERIVATIVES FOR THE INHIBITION OF DISEASES ASSOCIATED WITH ESTROGEN DEPRIVATION OR WITH AN ABERRANT PHYSIOLOGICAL RESPONSE TO ENDOGENOUS ESTROGEN
  申请人：ELI LILLY AND COMPANY

  公开号：EP1401446A1

  公开（公告）日：2004-03-31
• [EN] TETRAHYDROQUINOLIN DERIVATIVES FOR THE INHIBITION OF DISEASES ASSOCIATED WITH ESTROGEN DEPRIVATION OR WITH AN ABERRANT PHYSIOLOGICAL RESPONSE TO ENDOGENOUS ESTROGEN<br/>[FR] DERIVES DE TETRAHYDROQUINOLINE POUR L'INHIBITION DE MALADIES ASSOCIEES A L'ISOLEMENT D'OESTROGENES OU A UNE REPONSE PHYSIOLOGIQUE ABERRANTE A UN OESTROGENE ENDOGENE
  申请人：LILLY CO ELI

  公开号：WO2002094268A1

  公开（公告）日：2002-11-28

  The current invention provides methods for inhibiting a disease associated with estrogen deprivation and for inhibiting disease associated with an aberrant physiological response to endogenous estrogen comprising administering 2-substituted 1 ,2 ,3 ,4-tetrahydroquinolin-6-ols and derivatives thereof.