(3R,4aR,10aR)-1-methyl-3-[(1-methylimidazol-2-yl)sulfanylmethyl]-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinolin-6-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (3R,4aR,10aR)-1-methyl-3-[(1-methylimidazol-2-yl)sulfanylmethyl]-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinolin-6-ol
• 化学式: C₁₉H₂₅N₃OS
• 分子量: 343.5
• InChiKey: GRPDTQVFLZSLBL-FRFSOERESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Quinoline derivatives and their use in glaucoma and myopia
  申请人：Novartis AG

  公开号：EP1757601A1

  公开（公告）日：2007-02-28

  The present invention relates to novel benzo [g] quinoline derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.

  本发明涉及新型苯并[g]喹啉衍生物、它们的制备、它们作为药物的用途以及含有它们的药物组合物。
• Compositions comprising benzo(G)quinoline derivates and prostaglandin derivates
  申请人：Novartis AG

  公开号：EP1859802A2

  公开（公告）日：2007-11-28

  The present invention relates to a fixed combination of a benzo[g]quinoline derivative and a prostaglandin derivative, and their use as pharmaceuticals, especially for healing glaucoma.

  本发明涉及一种苯并[g]喹啉衍生物和一种前列腺素衍生物的固定组合，以及它们作为药物的用途，特别是用于治疗青光眼。
• Compositions comprising benzo (g) quinoline derivatives and prostaglandin derivatives
  申请人：Lambrou N. George

  公开号：US20070093507A1

  公开（公告）日：2007-04-26

  The present invention relates to a fixed combination of a benzo[g]quinoline derivative and a prostaglandin derivative, and their use as pharmaceuticals, especially for treating glaucoma.
• QUINOLINE DERIVATIVES
  申请人：Gull Peter

  公开号：US20080255176A1

  公开（公告）日：2008-10-16

  The present invention relates to novel benzo[g]quinoline derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.
• US7399768B2
  申请人：——

  公开号：US7399768B2

  公开（公告）日：2008-07-15