(9S,10R,11S)-7,9,15-trihydroxy-10-methoxypentacyclo[10.7.1.02,11.03,8.016,20]icosa-1,3(8),4,6,12(20),13,15-heptaen-17-one

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: (9S,10R,11S)-7,9,15-trihydroxy-10-methoxypentacyclo[10.7.1.02,11.03,8.016,20]icosa-1,3(8),4,6,12(20),13,15-heptaen-17-one
• 化学式: C₂₁H₁₈O₅
• 分子量: 350.4
• InChiKey: XAABSYWNTKOZII-SESVDKBCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Use of natural EGFR inhibitors to prevent side effects due to retinoid therapy, soaps, and other stimuli that activate the epidermal growth factor receptor
  申请人：——

  公开号：US20020137693A1

  公开（公告）日：2002-09-26

  Many human conditions, often skin conditions, are treated topically or orally with a retinoid such as retinoic acid or acetretin, which treatment often has the side effect of dry, irritated, and/or peeling skin. The use of soaps, detergents, chemical irritants, and such can also cause these same side effects. These side effects can be reduced or eliminated by the topical administration of an inhibitor, especially a natural inhibitor, of the epidermal growth factor receptor (EGFR), administered concomitantly with the retinoid, separately from the retinoid (such as on an as needed basis), or both. Administration of the two together is facilitated by a composition suitable for topical application and comprising both the retinoid and a natural EGFR inhibitor. Preferred natural inhibitors are genistein and other isoflavones extracted from natural occurring substances, or simple derivatives of such substances.

  人类的许多疾病，通常是皮肤病，都是通过局部或口服维甲酸（如维甲酸或乙酰维甲酸）来治疗的，这种治疗通常会产生皮肤干燥、刺激和/或脱皮的副作用。使用肥皂、清洁剂、化学刺激物等也会产生同样的副作用。通过局部使用表皮生长因子受体（EGFR）的抑制剂，特别是天然抑制剂，可以减少或消除这些副作用，这些抑制剂可以与维甲酸同时使用，也可以与维甲酸分开使用（如按需使用），或两者同时使用。适用于局部应用的组合物既包括维甲酸，也包括天然表皮生长因子受体抑制剂，有助于将两者同时施用。首选的天然抑制剂是从天然物质中提取的染料木素和其他异黄酮，或这类物质的简单衍生物。
• Use of natural EGFR inhibitors to prevent dermatitis, such as due to cleansers
  申请人：——

  公开号：US20040033207A1

  公开（公告）日：2004-02-19

  People's hands undergo daily exposure to hot, cold, and chemicals (such as cleansers). These exposures can cause dermatitis due to activation of the Epidermal Growth Factor Receptor (EGFR). One effect of activation of the EGFR is hyperproliferation of skin cells, which presents as rough, dry, and/or peeling hands, generally known as dermatitis. The use of a natural EGFR inhibitor, such as genistein or quercetin, can help to treat or prevent these kinds of dermatitis.

  人们的双手每天都要接触冷热和化学物质（如清洁剂）。这些接触会激活表皮生长因子受体（EGFR），从而引发皮炎。表皮生长因子受体活化的影响之一是皮肤细胞过度增殖，表现为双手粗糙、干燥和/或脱皮，一般称为皮炎。使用天然表皮生长因子受体抑制剂（如染料木素或槲皮素）有助于治疗或预防这类皮炎。
• USE OF NATURAL EGFR INHIBITORS TO PREVENT SIDE EFFECTS DUE TO RETINOID THERAPY, SOAPS, AND OTHER STIMULI THAT ACTIVATE THE EPIDERMAL GROWTH RECEPTOR
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：EP1370294A2

  公开（公告）日：2003-12-17
• US6638543B2
  申请人：——

  公开号：US6638543B2

  公开（公告）日：2003-10-28
• [EN] USE OF NATURAL EGFR INHIBITORS TO PREVENT SIDE EFFECTS DUE TO RETINOID THERAPY, SOAPS, AND OTHER STIMULI THAT ACTIVATE THE EPIDERMAL GROWTH RECEPTOR<br/>[FR] UTILISATION D'INHIBITEURS NATURELS DE EGFR PERMETTANT D'EMPECHER LES EFFETS SECONDAIRES INDUITS PAR UN TRAITEMENT PAR RETINOIDES, DES SAVONS, ET AUTRES STIMULI QUI ACTIVENT LE RECEPTEUR DU FACTEUR DE CROISSANCE EPIDERMIQUE
  申请人：UNIV MICHIGAN

  公开号：WO2002067988A2

  公开（公告）日：2002-09-06

  Many human conditions, often skin conditions, are treated topically or orally with a retinoid such as retinoic acid or acetretin, which treatment often has the side effect of dry, irritated, and/or peeling skin. The use of soaps, detergents, chemical irritants, and such can also cause these same side effects. These side effects can be reduced or eliminated by the topical administration of an inhibitor, especially a natural inhibitor, of the epidermal growth factor receptor (EGFR), administered concomitantly with the retinoid, separately from the retinoid (such as on an as-needed basis), or both. Administration of the two together is facilitated by a composition suitable for topical application and comprising both retinoid and a natural EGFR inhibitor. Preferred natural inhibitors are genistein and other isoflavones extracted from natural occurring substances, or simple derivatives of such substances.