1,3-dibromo-1-(4-fluorophenyl)-3-(4-bromophenyl)propane

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,3-dibromo-1-(4-fluorophenyl)-3-(4-bromophenyl)propane
• 英文别名: 1-Bromo-4-[1,3-dibromo-3-(4-fluorophenyl)propyl]benzene
• 化学式: C₁₅H₁₂Br₃F
• 分子量: 450.971
• InChiKey: PPZPCRDHXDERLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-氟苯乙烯 、 对溴苯甲醛 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 1,3-dibromo-1-(4-fluorophenyl)-3-(4-bromophenyl)propane
  参考文献：
  名称：

  A New Convenient, Efficient, and Regioselective Synthesis of 1,3-Diaryl- 1,3-dihalopropanes

  摘要：

  芳基醛与苯乙烯在三卤化硼存在下反应，生成1,3-二芳基-1,3-二卤丙烷，产率极高。

  DOI：

  10.1055/s-2004-829191

文献信息

• Lewis Acid Mediated Reactions of Aldehydes with Styrene Derivatives:  Synthesis of 1,3-Dihalo-1,3-diarylpropanes and 3-Chloro-1,3-diarylpropanols
  作者：George W. Kabalka、Zhongzhi Wu、Yuhong Ju、Min-Liang Yao

  DOI：10.1021/jo051298k

  日期：2005.12.1

  The reactions of aryl aldehydes with styrene derivatives, mediated by various boron Lewis acids, were investigated. 1,3-Dihalo-1,3-diarylpropanes were obtained in high yields with boron trihalides, while 3-chloro-1,3-diarylpropanols were obtained in good to excellent yields with phenylboron dichloride. Reactions involving nonenolizable aliphatic aldehydes, trans-cinnamaldehyde, and β-substituted styrenes

  研究了各种硼路易斯酸介导的芳基醛与苯乙烯衍生物的反应。用三卤化硼以高收率得到1,3-二卤代-1,3-二芳基丙烷，而用二氯化苯硼以高收率得到3-氯-1,3-二芳基丙醇。还首次研究了涉及不可烯化的脂族醛，反式肉桂醛和β-取代的苯乙烯的反应。
• METHOD FOR PRODUCING FULLERENE DERIVATIVE
  申请人：SHOWA DENKO K.K.

  公开号：US20170253567A1

  公开（公告）日：2017-09-07

  This method for producing a fullerene derivative is a method for producing a fullerene derivative having a partial structure shown by formula (1) by reacting a predetermined halogenated compound and two carbon atoms adjacent to each other for forming a fullerene skeleton in a mixed solvent of an aromatic solvent and an aprotic polar solvent having a C═O or S═O bond in the presence of at least one metal selected from the group comprising manganese, iron, and zinc; (in formula (1), C* are each carbon atoms adjacent to each other for forming a fullerene skeleton, A is a linking group having 1-4 carbon atoms for forming a ring structure with two C*, in which a portion thereof may be a substituted or condensed group).

  这种生产富勒烯衍生物的方法是通过在芳香溶剂和具有C═O或S═O键的无水极性溶剂的混合溶剂中，在锰、铁和锌中选择的至少一种金属存在的情况下，通过将预定卤化合物与相邻的两个碳原子反应以形成富勒烯骨架，从而产生具有由化学式（1）所示的部分结构的富勒烯衍生物；（在化学式（1）中，C*分别是相邻的两个碳原子，用于形成富勒烯骨架，A是具有1-4个碳原子的连接基团，用于与两个C*形成环结构，其中部分可能是取代或缩合基团）。
• Method for producing fullerene derivative
  申请人：SHOWA DENKO K.K.

  公开号：US11136298B2

  公开（公告）日：2021-10-05

  This method for producing a fullerene derivative is a method for producing a fullerene derivative having a partial structure shown by formula (1) by reacting a predetermined halogenated compound and two carbon atoms adjacent to each other for forming a fullerene skeleton in a mixed solvent of an aromatic solvent and an aprotic polar solvent having a C═O or S═O bond in the presence of at least one metal selected from the group comprising manganese, iron, and zinc; (in formula (1), C* are each carbon atoms adjacent to each other for forming a fullerene skeleton, A is a linking group having 1-4 carbon atoms for forming a ring structure with two C*, in which a portion thereof may be a substituted or condensed group).

  这种富勒烯衍生物的生产方法是在至少一种选自锰、铁和锌等金属的混合溶剂中，使预定的卤代化合物和相邻的两个碳原子发生反应，以形成富勒烯骨架，从而生产出具有式（1）所示部分结构的富勒烯衍生物； 式（1）中，C*是彼此相邻的碳原子，用于形成富勒烯骨架，A是具有 1-4 个碳原子的连接基团，用于与两个 C* 形成环状结构，其中一部分可以是取代基团或缩合基团）。