1,4-Dihydro-3-hydroxy-7-methoxy-2-(3-methylphenyl)-4-oxo-6-quinolinecarbonitrile | 371251-88-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,4-Dihydro-3-hydroxy-7-methoxy-2-(3-methylphenyl)-4-oxo-6-quinolinecarbonitrile
• 英文别名: 3-hydroxy-7-methoxy-2-(3-methylphenyl)-4-oxo-1H-quinoline-6-carbonitrile
• CAS: 371251-88-6
• 化学式: C₁₈H₁₄N₂O₃
• 分子量: 306.321
• InChiKey: IONFJMQMEPESJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  82.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Heterocycles that are inhibitors of IMPDH enzyme
  申请人：——

  公开号：US20020040022A1

  公开（公告）日：2002-04-04

  Compounds of the formula 1 wherein X 1 is C(O), —S(O)—, or —S(O) 2 —; X 2 is CR 3 or N; X 3 is —NH—, —O—, or —S—; X 4 is CR 4 or N; X 5 is CR 5 or N; and X 6 is CR 6 or N are useful as inhibitors of IMPDH enzyme. Thus, these compounds can be used as therapeutic agents for IMPDH-associated disorders.

  公式1中的化合物，其中X1是C(O)、—S(O)—或—S(O)2—；X2是CR3或N；X3是—NH—、—O—或—S—；X4是CR4或N；X5是CR5或N；X6是CR6或N，可用作IMPDH酶的抑制剂。因此，这些化合物可作为治疗IMPDH相关疾病的治疗剂。
• HETEROCYCLES THAT ARE INHIBITORS OF IMPDH ENZYME
  申请人：Bristol-Myers Squibb Co.

  公开号：EP1276739A2

  公开（公告）日：2003-01-22
• US6919335B2
  申请人：——

  公开号：US6919335B2

  公开（公告）日：2005-07-19
• [EN] HETEROCYCLES THAT ARE INHIBITORS OF IMPDH ENZYME<br/>[FR] HETEROCYCLES UTILES EN TANT QU'INHIBITEURS DE L'ENZYME IMPDH
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2001081340A2

  公开（公告）日：2001-11-01

  Compounds of formula (I) wherein X1 is C(O), -S(O)-, or -S(O)¿2?-; X?2 is CR3¿ or N; X3 is -NH-, -O-, or -S-; X?4 is CR4¿ or N; X?5 is CR5¿ or N; and X?6 is CR6¿ or N are useful as inhibitors of IMPDH enzyme. Thus, these compounds can be used as therapeutic agents for IMPDH- associated disorders.