N'-methyl-N-(2-naphthalen-2-ylquinolin-4-yl)-N'-[3-[(2-naphthalen-2-ylquinolin-4-yl)amino]propyl]propane-1,3-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N'-methyl-N-(2-naphthalen-2-ylquinolin-4-yl)-N'-[3-[(2-naphthalen-2-ylquinolin-4-yl)amino]propyl]propane-1,3-diamine
• 化学式: C₄₅H₄₁N₅
• 分子量: 651.8
• InChiKey: SUGZZDDDUWZWKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.7
• 重原子数：
  50
• 可旋转键数：
  12
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• ANTAGONISM OF IMMUNOSTIMULATORY CPG-OLIGONUCLEOTIDES BY 4-AMINOQUINOLINES AND OTHER WEAK BASES
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：EP1377554A1

  公开（公告）日：2004-01-07
• US6479504B1
  申请人：——

  公开号：US6479504B1

  公开（公告）日：2002-11-12
• [EN] ANTAGONISM OF IMMUNOSTIMULATORY CPG-OLIGONUCLEOTIDES BY 4-AMINOQUINOLINES AND OTHER WEAK BASES<br/>[FR] ANTAGONISME DES OLIGONUCLEOTIDES CPG IMMUNOSTIMULATEURS PAR DES 4-AMINOQUINOLINES ET AUTRES BASES FAIBLES
  申请人：UNIV IOWA STATE RES FOUND

  公开号：WO2000076982A1

  公开（公告）日：2000-12-21

  The present invention relates generally to the field of immunology. More particularly it concerns compositions and methods for inhibiting stimulation of the immune system. The compounds and methods comprise compounds that are analogs and derivatives of chloroquine, such as 4-aminoquinolines, and other weak bases. They can be used in preventative and therapeutic treatments of autoimmune diseases and phenomena, transplant rejection such as host-versus-graft disease, and sepsis.