N1-(7-Chloro-quinolin-4-yl)-N2-(3-chloro-benzyl)-2-methyl-propane-1,2-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N1-(7-Chloro-quinolin-4-yl)-N2-(3-chloro-benzyl)-2-methyl-propane-1,2-diamine
• 英文别名: 2-N-[(3-chlorophenyl)methyl]-1-N-(7-chloroquinolin-4-yl)-2-methylpropane-1,2-diamine
• 化学式: C₂₀H₂₁Cl₂N₃
• 分子量: 374.313
• InChiKey: OEACUYDRIGXJIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Treatment of dna damage related disorders
  申请人：Kastan B Michael

  公开号：US20050124653A1

  公开（公告）日：2005-06-09

  The present invention provides methods and compositions for the treatment of DNA damage related disorders. One embodiment of the invention is a prophylactic method for the prevention of cancer using a chloroquine compound. Another embodiment is a method for the inhibition of side effects associated with chemotherapeutic and radiotherapeutic agents using chloroquine compounds.

  本发明提供了治疗 DNA 损伤相关疾病的方法和组合物。本发明的一个实施方案是使用氯喹化合物预防癌症的方法。另一个实施方案是使用氯喹化合物抑制化疗和放疗药物相关副作用的方法。
• ANTIMALARIAL QUINOLIN DERIVATIVES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0876346B1

  公开（公告）日：2001-07-25
• Treatment of radiation disorders
  申请人：Kastan B. Michael

  公开号：US20050014785A1

  公开（公告）日：2005-01-20

  The present invention provides methods and compositions for the treatment of DNA damage related disorders. One embodiment is a method for the inhibition of side effects associated with chemotherapeutic and radiotherapeutic agents using chloroquine compounds. Another embodiment is a method for treatment and/or prevention of lethal or sub-lethal radiation toxicities associated with terrorist acts or war.
• Treatment of DNA damage related disorders
  申请人：Kastan B. Michael

  公开号：US20050032834A1

  公开（公告）日：2005-02-10

  The present invention provides methods and compositions for prophylaxis and treatment of a variety of disorders including DNA damage related disorders, cancer, ischemia, oxidative stress, atherosclerosis, and stroke using a chloroquine compound.
• Opthalmic pharmaceutical compositions and methods for treating ocular inflammation
  申请人：Raut Rajeev

  公开号：US20060014786A1

  公开（公告）日：2006-01-19

  The present invention relates to novel ophthalmic pharmaceutical compositions comprising an inflammation-treating amount of a 4-aminoquinoline compound, derivative, isomers, or chemical salts, and methods for using these compositions for the treatment of ocular inflammatory conditions by topical administration directly to the eye.