2-amino-4-benzoyl-6-(propylsulfanyl)pyridine-3,5-dicarbonitrile

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-amino-4-benzoyl-6-(propylsulfanyl)pyridine-3,5-dicarbonitrile
• 英文别名: 2-Amino-4-(phenylcarbonyl)-6-(propylsulfanyl)pyridine-3,5-dicarbonitrile；2-amino-4-benzoyl-6-propylsulfanylpyridine-3,5-dicarbonitrile
• 化学式: C₁₇H₁₄N₄OS
• mdl: MFCD26097711
• 分子量: 322.39
• InChiKey: COENQNNEPZUFHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  129
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丙烷-1-硫醇 、 potassium 2-benzoyl-1,1,3,3-tetracyanopropenide 在 sodium 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以68%的产率得到2-amino-4-benzoyl-6-(propylsulfanyl)pyridine-3,5-dicarbonitrile
  参考文献：
  名称：

  Synthesis of novel 4-acyl-2-amino-6-sulfanylpyridine-3,5-dicarbonitriles

  摘要：

  An efficient one-step synthesis of novel 4-acyl-2-amino-3,5-dicarbonitrile-6-sulfanylpyridines has been developed via the reaction of 2-acyl-1,1,3,3-tetracyanopropenides with thiols in DMSO containing dimsyl sodium. 2-Amino-3,5-dicarbonitrile-6-sulfanylpyridines are the subject of considerable interest due to their wide range of pharmaceutical, biological, and medicinal applications and currently serve as a 'privileged scaffold' due to their potential therapeutic applications. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.09.130

文献信息

• Synthesis of novel 4-acyl-2-amino-6-sulfanylpyridine-3,5-dicarbonitriles
  作者：Arthur A. Grigor’ev、Sergey V. Karpov、Yakov S. Kayukov、Mikhail Yu. Belikov、Oleg E. Nasakin

  DOI：10.1016/j.tetlet.2015.09.130

  日期：2015.11

  An efficient one-step synthesis of novel 4-acyl-2-amino-3,5-dicarbonitrile-6-sulfanylpyridines has been developed via the reaction of 2-acyl-1,1,3,3-tetracyanopropenides with thiols in DMSO containing dimsyl sodium. 2-Amino-3,5-dicarbonitrile-6-sulfanylpyridines are the subject of considerable interest due to their wide range of pharmaceutical, biological, and medicinal applications and currently serve as a 'privileged scaffold' due to their potential therapeutic applications. (C) 2015 Elsevier Ltd. All rights reserved.