4-(4-Aminophenyl)sulfonylaniline;2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(4-Aminophenyl)sulfonylaniline;2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol
• 化学式: C30H38ClN5O3S
• 分子量: 584.2
• InChiKey: OCEJPEAMKKDGLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.47
• 重原子数：
  40
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Compositions and methods containing substituted quinolines and substituted diphenylsulfones
  申请人：Giulian J Dana

  公开号：US20060035929A1

  公开（公告）日：2006-02-16

  Combination therapies of substituted quinolines and substituted diphenyl sulfones are disclosed. More specifically, compositions containing substituted quinolines and substituted diphenyl sulfones are disclosed. In addition, methods of using the compositions in the treatment of neurodegenerative disorders, including, inter alia, Alzheimer's dementia, HIV-1 associated dementia, and Creutzfeld-Jakob disease are also disclosed.

  本研究公开了取代的喹啉类化合物和取代的二苯砜类化合物的组合疗法。更具体地说，公开了含有取代喹啉和取代二苯砜的组合物。此外，还公开了使用这些组合物治疗神经退行性疾病的方法，包括阿尔茨海默氏痴呆症、HIV-1 相关痴呆症和克雅氏病等。
• COMPOSITIONS CONTAINING SUBSTITUTED QUINOLINES AND SUBSTITUTED DIPHENYL SULFONES AND METHODS OF USE
  申请人：Giulian J. Dana

  公开号：US20070129439A1

  公开（公告）日：2007-06-07

  Combination therapies of substituted quinolines and substituted diphenyl sulfones are disclosed. More specifically, compositions containing substituted quinolines and substituted diphenyl sulfones are disclosed. In addition, methods of using the compositions in the treatment of neurodegenerative disorders, including, inter alia, Alzheimer's dementia, HIV-1 associated dementia, and Creutzfeld-Jakob disease are also disclosed.