8-methyl-7-nitro-N-(2-piperidin-1-ylethyl)quinolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-methyl-7-nitro-N-(2-piperidin-1-ylethyl)quinolin-4-amine
• 化学式: C₁₇H₂₂N₄O₂
• 分子量: 314.387
• InChiKey: KCWKKSGQAPRKCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  74
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  8-Methyl-7-nitro-1H-quinolin-4-one 在 三氯氧磷 作用下， 反应 5.0h， 生成 8-methyl-7-nitro-N-(2-piperidin-1-ylethyl)quinolin-4-amine
  参考文献：
  名称：

  Synthesis and antibacterial activity of new 4-alkoxy, 4-aminoalkyl and 4-alkylthioquinoline derivatives

  摘要：

  4-Alkoxy-8-methyl-7-nitroquinolines, 4-alkylamino-8-methyl-7-nitroquinolines, 4-alkoxy-2,8-dimethylquinolines, 4-alkylthioquinolines were prepared from 8-methyl-7-nitro-4-quinolone, 8-methyl-7-nitro-4-chloro-quinoline, 2,8-dimethyl-4-quinolone and 4-hydroxyquinoline used as starting material. Compounds were characterized from H-1 and C-13 NMR spectra. These drugs were tested against selected gram-, gram+ and mycobacteria strains. A promising activity was observed against Mycobacterium smegmatis. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80076-2

文献信息

• [EN] NOVEL INHIBITORS OF RESISTANCE TO BACTERIA ANTIBIOTICS<br/>[FR] NOUVEAUX INHIBITEURS DE LA RESISTANCE AUX ANTIBIOTIQUES DES BACTERIES
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2003097055A2

  公开（公告）日：2003-11-27

  L'invention vise de nouveaux inhibiteurs de la résistance aux antibiotiques et leurs applications. Les inhibiteurs sont caractérisés en ce qu'ils répondent à la formule (I) dans laquelle :- R3 représente un groupement fonctionnel choisi parmi les groupes -OH, -OR, -O-R-NR'R', -NH2, -NHR, -NRR, -NH-R-NR'R' -SH, -SR, -S-R-NR'R'-R1, R2, identiques ou différents l'un de l'autre, représentent un hydrogène, un groupement fonctionnel choisi parmi les groupes -OH, -OR, -COH, -COR, -COOH, -COOR, -NH2, -NHR, -NRR, -SH, -SR, un halogène, pseudohalogène, un alkyle, un aryle, une hétéroalkyle ou un hétérocycloaryle,ces molécules étant le cas échéant sous forme hydratée ou semi-hydratée,et leurs sels pharmaceutiquement acceptables.
• Synthesis and antibacterial activity of new 4-alkoxy, 4-aminoalkyl and 4-alkylthioquinoline derivatives
  作者：Marie-Gratia Kayirere、Abdallah Mahamoud、Jacqueline Chevalier、Jean-Claude Soyfer、Andrée Crémieux、Jacques Barbe

  DOI：10.1016/s0223-5234(99)80076-2

  日期：1998.1

  4-Alkoxy-8-methyl-7-nitroquinolines, 4-alkylamino-8-methyl-7-nitroquinolines, 4-alkoxy-2,8-dimethylquinolines, 4-alkylthioquinolines were prepared from 8-methyl-7-nitro-4-quinolone, 8-methyl-7-nitro-4-chloro-quinoline, 2,8-dimethyl-4-quinolone and 4-hydroxyquinoline used as starting material. Compounds were characterized from H-1 and C-13 NMR spectra. These drugs were tested against selected gram-, gram+ and mycobacteria strains. A promising activity was observed against Mycobacterium smegmatis. (C) Elsevier, Paris.