Disodium;[(10-methylacridin-9-ylidene)-phenoxymethyl] phosphate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Disodium;[(10-methylacridin-9-ylidene)-phenoxymethyl] phosphate
• 化学式: C21H16NNa2O5P
• 分子量: 439.3
• InChiKey: AIYVDWIBXYHZOX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.58
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  84.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• METHOD OF JUDGING LEUKEMIA, PRE-LEUKEMIA OR ALEUKEMIC MALIGNANT BLOOD DISEASE AND DIAGNOSTIC THEREFOR
  申请人：TOKAI UNIVERSITY

  公开号：EP1496360A1

  公开（公告）日：2005-01-12

  The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome, a method of diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells, and a method of diagnosing the graft versus host disease, each of said methods comprising quantifying stem cell growth factor (SCGF). The present invention also makes it possible to provide an agent for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases and an agent for diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells or an agent for diagnosing graft versus host disease (GVHD), each containing as an active ingredient an antibody reacting with stem cell growth factor (SCGF).

  本发明涉及一种白血病、白血病前期或白血病恶性血液病的诊断方法，一种白血病与白血病前期或白血病恶性血液病的鉴别方法，一种再生障碍性贫血与骨髓增生异常综合征的鉴别方法、诊断造血干细胞移植后造血干细胞移植延迟的方法，以及诊断移植物抗宿主疾病的方法，上述每种方法都包括量化干细胞生长因子（SCGF）。本发明还能提供一种用于诊断白血病、白血病前期或白血病恶性血液疾病的制剂，以及一种用于诊断造血干细胞移植后造血干细胞移植延迟的制剂或一种用于诊断移植物抗宿主疾病（GVHD）的制剂，每种制剂都含有与干细胞生长因子（SCGF）反应的抗体作为活性成分。
• IMMUNOASSAY IN WHICH NON-SPECIFIC REACTION IS SUPPRESSED AND REAGENT THEREFORE
  申请人：KYOWA MEDEX CO., LTD.

  公开号：EP1767942A1

  公开（公告）日：2007-03-28

  A method for immunologically determining an analyte in which a nonspecific reaction is suppressed, which comprises the steps of: allowing an enzyme-labeled antibody in which an enzyme is bound as a label to a first antibody that specifically binds to the analyte, to react with the sample in an aqueous medium to form an immune complex of the analyte and the enzyme-labeled antibody, said enzyme-labeled antibody substantially containing only one or plural number of enzyme-labeled antibodies selected from the group consisting of enzyme-labeled antibodies having a binding ratio between the first antibody and the enzyme of 1:1, 1:2, 1:3 and 2:1, respectively, and measuring the enzyme activity of the immune complex.

  一种抑制非特异性反应的免疫测定分析物的方法，它包括以下步骤 让酶标记抗体（其中酶作为标记与特异性结合分析物的第一抗体结合）在水介质中与样品反应，形成分析物与酶标记抗体的免疫复合物，所述酶标记抗体实质上只含有一种或多种酶标记抗体，这些酶标记抗体选自第一抗体与酶的结合比分别为1:1、1:2、1:3和2:1的酶标记抗体组：分别为 1:1、1:2、1:3 和 2:1，并测量免疫复合物的酶活性。
• METHOD OF IMMUNOASSAY OF COMPONENT TO BE MEASURED
  申请人：Kyowa Medex CO., LTD.

  公开号：EP2085782A1

  公开（公告）日：2009-08-05

  A method of immunoassaying a component to be measured in a sample containing hemoglobin, which comprises reacting a component to be measured in a sample containing hemoglobin with an antibody capable of binding to the component in the presence of a bile acid derivative different from a bile acid derivative that is inherently contained in the sample; a method of suppressing an interference of hemoglobin in immunoassaying a component to be measured in a sample containing hemoglobin, which comprises reacting a component to be measured in a sample containing hemoglobin with an antibody capable of binding to the component in the presence of a bile acid derivative different from a bile acid derivative that is inherently contained in the sample; a reagent of immunoassay of a component to be measured in a sample containing hemoglobin, which comprises a bile acid derivative, are described.

  一种免疫测定含有血红蛋白的样品中待测组分的方法，它包括使含有血红蛋白的样品中的待测组分与能在胆汁酸衍生物存在下与该组分结合的抗体反应，该胆汁酸衍生物不同于样品中固有含有的胆汁酸衍生物；本发明描述了一种抑制血红蛋白对免疫测定含血红蛋白样品中待测组分的干扰的方法，该方法包括使含血红蛋白样品中的待测组分与一种能与该组分结合的抗体反应，该抗体存在于一种胆汁酸衍生物中，该胆汁酸衍生物不同于样品中固有的胆汁酸衍生物；一种免疫测定含血红蛋白样品中待测组分的试剂，该试剂包括一种胆汁酸衍生物。
• DEVICE FOR DETECTION OF INFLUENZA VIRUS
  申请人：National University Corporation University Of Toyama

  公开号：EP2309264A1

  公开（公告）日：2011-04-13

  A device for detecting or quantifying influenza viruses in a sample, which comprises a detection region having a human anti-influenza virus nucleoprotein antibody immobilized onto a support, a sample supply region, and a sample-migrating region; and a kit for detecting or quantifying influenza viruses, which comprises a solid phase in which a human anti-influenza virus nucleoprotein antibody is fixed onto a carrier.

  一种用于检测或定量样品中流感病毒的装置，它包括一个检测区、一个样品供应区和一个样品迁移区，检测区的支撑物上固定有人类抗流感病毒核蛋白抗体；以及一种用于检测或定量流感病毒的试剂盒，它包括一个固相，在固相中，人类抗流感病毒核蛋白抗体被固定在载体上。
• METHOD FOR ASSAYING COMPONENT TO BE ASSAYED IN SPECIMEN AND ASSAY KIT
  申请人：Kyowa Medex CO., LTD.

  公开号：EP2495565A1

  公开（公告）日：2012-09-05

  Methods and kits for measuring a component to be measured in a specimen are provided, which enable accurate measurements that are not affected by reaction temperatures or such when measuring the component to be measured, such as antigens. Methods for measuring a component to be measured, which comprise: reacting, in the presence of a fatty acid alkanolamide, a component to be measured in a specimen with a first antibody which binds to the component to be measured; then reacting a labeled second antibody, in which a label is bound to a second antibody that binds to the component to be measured, to form an immunocomplex comprising the first antibody, the component to be measured, and the labeled second antibody; and measuring the amount of the label in the formed immunocomplex; and kits for measuring the component to be measured in a specimen used in the measurement methods.

  本发明提供了用于测量样本中待测成分的方法和试剂盒，在测量抗原等待测成分时，这些方法和试剂盒可实现不受反应温度等影响的精确测量。 测量待测成分的方法包括在脂肪酸烷醇酰胺存在的情况下，使试样中的待测组分与第一抗体反应，第一抗体与待测组分结合；然后使标记的第二抗体反应，标记与第二抗体结合，第二抗体与待测组分结合，形成由第一抗体、待测组分和标记的第二抗体组成的免疫复合物；测量所形成的免疫复合物中的标签量；以及用于测量方法中所用样本中待测成分的试剂盒。