N,N-diethylethanamine;1,1,1,3,3,3-hexafluoropropan-2-ol

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: N,N-diethylethanamine;1,1,1,3,3,3-hexafluoropropan-2-ol
• 化学式: C9H17F6NO
• 分子量: 269.23
• InChiKey: IYFDBHFKUAUIPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.82
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,2,2-trifluoroethyl fluorosulfate 、 六氟异丙醇 、 三乙胺 以4%的产率得到
  参考文献：
  名称：

  KINKEAD, S. A.;KIMAR, RAMESH, C.;SHREEVE, J. M., J. AMER. CHEM. SOC., 1984, 106, N 24, 7496-7500

  摘要：

  DOI：

文献信息

• Methods for the Delivery of Oligomeric Compounds
  申请人：Juliano Rudolph L.

  公开号：US20080199960A1

  公开（公告）日：2008-08-21

  The presently disclosed subject matter relates to the delivery of oligonucleotides to cells through the delivery of a composition or reagent comprising a hybridization complex comprising a first antisense oligonucleotide which is modified to have a higher stability against degradation, and a second sense oligonucleotide which is prone to degradation. The presently disclosed subject matter furthermore relates to dendrimeric bioconjugates and compositions or reagents comprising them, wherein the bioconjugate comprises a conjugate moiety coupled to a dendrimeric structure and to their use to deliver oligomeric compounds including oligonucleotides or duplexes, as described above, to cells for modulation of gene expression (i.e. antisense or antigene therapy/research, RNA interference).