N-[4-[2-[(4-nitrophenyl)sulfonylamino]ethylamino]-3,4-dioxo-1-phenylbutan-2-yl]-2-(2-phenylethynyl)quinoline-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[4-[2-[(4-nitrophenyl)sulfonylamino]ethylamino]-3,4-dioxo-1-phenylbutan-2-yl]-2-(2-phenylethynyl)quinoline-4-carboxamide
• 化学式: C36H29N5O7S
• 分子量: 675.7
• InChiKey: JVCMDGYBTFKBQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  49
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  189
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Endoluminal medical device for local delivery of cathepsin inhibitors, method of making and treating
  申请人：Biggs P. David

  公开号：US20070293937A1

  公开（公告）日：2007-12-20

  An endoluminal medical device comprises a drug release system that releases a cathepsin inhibitor at a predetermined location within a lumen of a patient. The endoluminal devices and methods of treatment of disease can treat illnesses such as aneurysms and aortic dissections.