(Z)-4-(3-cyclopentyloxy-4-methoxyphenyl)-3-methoxycarbonylbut-3-enoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (Z)-4-(3-cyclopentyloxy-4-methoxyphenyl)-3-methoxycarbonylbut-3-enoic acid
• 化学式: C₁₈H₂₂O₆
• 分子量: 334.4
• InChiKey: OAQPEPHQTOIVEK-LCYFTJDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity
  申请人：——

  公开号：US20030195257A1

  公开（公告）日：2003-10-16

  Formula (I) compounds are described, where the groups are defined in the description, as well as processes for their preparation and their use as medicaments, particularly as selective phosphodiesterase IV inhibitors. 1

  描述了Formula (I)化合物，其中群在描述中定义，以及它们的制备过程和用途，特别是作为选择性磷酸二酯酶IV抑制剂的药物。
• COMPOUNDS USEFUL FOR THE PREPARATION OF MEDICAMENTS WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY
  申请人：SIGMA-TAU IndustrieFarmaceutiche Riunite S.p.A.

  公开号：EP1292563A2

  公开（公告）日：2003-03-19
• US7169808B2
  申请人：——

  公开号：US7169808B2

  公开（公告）日：2007-01-30
• [EN] COMPOUNDS USEFUL FOR THE PREPARATION OF MEDICAMENTS WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY<br/>[FR] COMPOSES UTILES POUR LA PREPARATION DE MEDICAMENTS EXERÇANT UNE ACTIVITE D'INHIBITION DE LA PHOSPHODIESTERASE IV
  申请人：SIGMA TAU IND FARMACEUTI

  公开号：WO2002000593A2

  公开（公告）日：2002-01-03

  Formula (I) compounds are described, where R1 and R2, which may be the same or different, are halogen, hydroxy, alkoxy, cycloalkoxy; X is (CH2)n-, -CO-(CH2)n-, where n is 1 or 2, or X is -CH=; R3 is -OH, -NHOH, alkoxy; Y is H, -(CH2)nCOR4, -COR4, -NHR5, where R4 is -OH, -NHOH, alkoxy, R5 is H, alkanoyl optionally substituted by halogens; n is an integer between 1 and 4; as well as processes for their preparation and their use as medicaments; particularly as selective phosphodiesterase IV inhibitors.
• [EN] 2,6,7-SUBSTITUTED TETRALINES USEFUL FOR THE PREPARATION OF MEDICAMENTS WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY<br/>[FR] TETRALINES 2,6,7-SUBSTITUEES CONVENANT A L'ELABORATION DE MEDICAMENTS INHIBITEURS DE LA PHOSPHODIESTERASE IV
  申请人：SIGMA TAU IND FARMACEUTI

  公开号：WO2002000609A2

  公开（公告）日：2002-01-03

  Formula (I) compounds are described where the groups are as defined in the description, as well as processes for their preparation and their use as medicaments, particularly for the preparation of medicaments with phosphodiesterase IV inhibitory activity.