7-Methoxy-2-(2-phenylethylamino)quinoline-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-Methoxy-2-(2-phenylethylamino)quinoline-3-carboxylic acid
• 化学式: C₁₉H₁₈N₂O₃
• 分子量: 322.4
• InChiKey: SZBBBRJDVWBXGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  71.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Chemical compounds
  申请人：Burgess L. Joelle

  公开号：US20060106058A1

  公开（公告）日：2006-05-18

  3-carboxy quinoline derivatives, which are useful as YAK3 inhibitors are described herein. The described invention also includes methods of making such 3-carboxy quinoline derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate YAK3 activity.

  本文描述了一种有用于YAK3抑制剂的3-羧基喹啉衍生物。所述发明还包括制备这种3-羧基喹啉衍生物的方法，以及使用它们治疗由不适当的YAK3活性介导的疾病的方法。
• CHEMICAL COMPOUNDS
  申请人：SmithKline Beecham Corporation

  公开号：EP1556379A2

  公开（公告）日：2005-07-27
• EP1556379A4
  申请人：——

  公开号：EP1556379A4

  公开（公告）日：2007-06-13
• US7482455B2
  申请人：——

  公开号：US7482455B2

  公开（公告）日：2009-01-27
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSES CHIMIQUES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2004034985A2

  公开（公告）日：2004-04-29

  3-carboxy quinoline derivatives, which are useful as YAK3 inhibitors are described herein. The described invention also includes methods of making such 3-carboxy quinoline derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate YAK3 activity.