7-chloro-1-ethyl-6-(phenethylamino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-chloro-1-ethyl-6-(phenethylamino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• 英文别名: 7-Chloro-1-ethyl-4-oxo-6-(2-phenylethylamino)quinoline-3-carboxylic acid
• 化学式: C₂₀H₁₉ClN₂O₃
• 分子量: 370.835
• InChiKey: ARGNTHRORWMILQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof
  申请人：Johnstone B.C. Timothy

  公开号：US20060178516A1

  公开（公告）日：2006-08-10

  Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of γ-aminobutyric acid (GABA) via a novel site on the GABA A receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABA A receptor complex.

  介绍了取代的喹诺酮羧酸及其衍生物。这些化合物通过γ-氨基丁酸（GABA）上的一个新位点调节γ-氨基丁酸（GABA）的作用。 A 受体复合物上的一个新位点以治疗相关的方式调节γ-氨基丁酸（GABA）的作用，可用于改善可通过调节 GABA A 受体复合物的调节作用。
• SUBSTITUTED QUINOLONE CARBOXYLIC ACIDS, THEIR DERIVATIVES, SITE OF ACTION, AND USES THEREOF
  申请人：The Regents of the University of California

  公开号：EP1503759A2

  公开（公告）日：2005-02-09
• EP1503759A4
  申请人：——

  公开号：EP1503759A4

  公开（公告）日：2006-02-15
• Substituted Quinolone Carboxylic Acids, Their Derivatives, Site of Action, And Uses Thereof
  申请人：Johnstone Timothy B.C.

  公开号：US20080176897A1

  公开（公告）日：2008-07-24

  Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of γ-aminobutyric acid (GABA) via a novel site on the GABA A receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABA A receptor complex.
• US7355047B2
  申请人：——

  公开号：US7355047B2

  公开（公告）日：2008-04-08