1-[2-oxo-4-(trifluoromethyl)-1H-quinolin-6-yl]-3-(2-propan-2-ylphenyl)thiourea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-[2-oxo-4-(trifluoromethyl)-1H-quinolin-6-yl]-3-(2-propan-2-ylphenyl)thiourea
• 化学式: C₂₀H₁₈F₃N₃OS
• 分子量: 405.4
• InChiKey: ALYNKKIIMILDOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  85.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Urea and thiourea derivatives
  申请人：——

  公开号：US20040266820A1

  公开（公告）日：2004-12-30

  The invention is directed to a new class of quinolin-zene and z-exc chromen compounds that have been derivatized at the 6-position with a urea or this urea moet, and to then use as androgen antagonists.

  本发明涉及一类新型的喹啉-苯和z-环香豆素化合物，它们在6位经尿素或尿素酰基衍生化，以作为雄激素拮抗剂。
• UREA AND THIOUREA DERIVATIVES
  申请人：Warner-Lambert Company LLC

  公开号：EP1603882A2

  公开（公告）日：2005-12-14
• US7074933B2
  申请人：——

  公开号：US7074933B2

  公开（公告）日：2006-07-11
• [EN] UREA AND THIOUREA DERIVATIVES<br/>[FR] UREE ET DERIVES DE THIO-UREE
  申请人：WARNER LAMBERT CO

  公开号：WO2004072044A2

  公开（公告）日：2004-08-26

  The invention is directed to a new class of quinolin-2-one and chromen-2-one compounds that have been derivatized at the 6-position with a urea or thio urea moiety of formula (I) in which M, R1, R2, X and A are as defined in the claims, and to their use as androgen antagonists.