N,3-dihydroxy-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-(pyridin-4-ylmethyl)propanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N,3-dihydroxy-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-(pyridin-4-ylmethyl)propanamide
• 化学式: C₂₆H₂₅N₃O₄
• 分子量: 443.5
• InChiKey: ZFJFQMJTZHNIAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme
  申请人：——

  公开号：US20040063698A1

  公开（公告）日：2004-04-01

  The present invention provides compounds of Formula (I): 1 or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, R 1 , R 2 , R 3 , R 4 , Z, U, X, Y, Z a , and n are defined are as defined herein, which are useful as inhibitors of matrix metalloproteinases (MMP) and/or TNF-&agr; converting enzyme (TACE), or a combination thereof.

  本发明提供了公式（I）的化合物：1或其立体异构体或药学上可接受的盐形式，其中变量A、R1、R2、R3、R4、Z、U、X、Y、Za和n的定义如本文所述，其作为基质金属蛋白酶（MMP）和/或TNF-α转化酶（TACE）的抑制剂或其组合物是有用的。
• US7102008B2
  申请人：——

  公开号：US7102008B2

  公开（公告）日：2006-09-05
• [EN] HYDANTOIN DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-ALPHA CONVERTING ENZYME<br/>[FR] DERIVES D'YHYDANTOINE UTILISES COMME INHIBITEURS DE METALLOPROTEASES MATICIELLES ET/OU D'ENZYME DE CONVERSION DE TNF-ALPHA
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2004012663A2

  公开（公告）日：2004-02-12

  The present invention provides compounds of Formula (I): CHEMICAL STRUCTURE] or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, R1, R2, R3, R4, Z, U, X, Y, Za, and n are defined are as defined herein, which are useful as inhibitors of matrix metalloproteinases (MMP) and/or TNF-a converting enzyme (TACE), or a combination thereof.