Clobetasone 17-Propionate | 25122-56-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Clobetasone 17-Propionate
• 英文别名: [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
• CAS: 25122-56-9
• 化学式: C₂₅H₃₀ClFO₅
• 分子量: 465.0
• InChiKey: VAUBWHIQMRKGBN-BHHHYXKXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  77.5
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE MODULATION DE L'ACTIVITÉ DE LA DÉSHYDROGÉNASE À CHAÎNE COURTE
  申请人：UNIV CASE WESTERN RESERVE

  公开号：WO2018218251A1

  公开（公告）日：2018-11-29

  Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

  化合物的15-PGDH活性调节方法、组织前列腺素水平调节、疾病治疗、疾病紊乱或希望调节15-PGDH活性和/或前列腺素水平的状况包括本文描述的15-PGDH抑制剂。
• Pharmaceutical Compositions Comprising Capsaicin Esters for Treating Pain and Cold Sores
  申请人：Singh Chandra U.

  公开号：US20140134261A1

  公开（公告）日：2014-05-15

  The present invention relates to pharmaceutical compositions comprising ester(s) of capsaicin and at least one other agent selected from salicylates, menthol, boswellic acids, DMSO, methyl sulfonylmethane, NSAIDs, corticosteroids, emu oil, opioid agonists and antagonists, NMDA antagonists, tramadol, hyaluronic acid, α2δ ligands, santalol, santalyl acetate, amyris alcohol, amyris acetate, aloe vera gel and aloe vera juice, for improved therapeutic properties. Further, the present invention relates to pharmaceutical compositions comprising high concentrations of ester(s) of capsaicin. Further, the present invention relates to a method of relieving pain due to various diseases in subjects by administering the pharmaceutical compositions of the invention. Further, the present invention relates to methods of relieving fever blisters due to cold sores in subjects by administering the pharmaceutical compositions comprising an ester of capsaicin and one other agent selected from santalol, santalyl acetate, amyris alcohol and amyris acetate.

  本发明涉及含有辣椒素酯及至少一种来自水杨酸酯、薄荷脑、乳香酸、二甲基亚砜、甲基亚砜、非甾体抗炎药、皮质类固醇、鸸鹋油、阿片受体激动剂和拮抗剂、NMDA受体拮抗剂、曲马多、透明质酸、α2δ受体配体、檀香醇、檀香醋酸酯、白檀醇、白檀醋酸酯、芦荟凝胶和芦荟汁的药物组合物，用于改善治疗特性。此外，本发明涉及含有高浓度辣椒素酯的药物组合物。此外，本发明涉及通过给予本发明的药物组合物来减轻受试者因各种疾病而导致的疼痛的方法。此外，本发明涉及通过给予含有辣椒素酯及来自檀香醇、檀香醋酸酯、白檀醇和白檀醋酸酯中的一种的药物组合物来减轻受试者因感冒引起的发热疱疹的方法。
• PLASTER
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP1293199A1

  公开（公告）日：2003-03-19

  A patch comprising a laminate having an expansible support and an adhesive layer laminated on the support; and a release sheet, attached onto the adhesive layer, having perforations formed with a predetermined interval;    wherein the laminate when formed into a test piece having a longer side of 20 cm and a shorter side of 5 cm exhibits a load of 0.98 to 14.71 N/5 cm in both longer and shorter side directions at the time of 50% elongation, and a 50% elongation recovery ratio of 50 to 95% in both longer and shorter side directions.

  一种贴片，包括一种层压板，该层压板具有可伸缩的支承层和层压在支承层上的粘合剂层；以及一种附着在粘合剂层上的离型膜，该离型膜具有以预定间隔形成的穿孔； 其中，当层压板被制成长边为 20 厘米、短边为 5 厘米的测试片时，在伸长 50%时，在长边和短边方向上的载荷均为 0.98 至 14.71 牛/5 厘米，在长边和短边方向上的 50%伸长恢复率均为 50 至 95%。
• Combination antiperspirant and antimicrobial compositions
  申请人：Xantech Pharmaceuticals, Inc.

  公开号：EP1362581A2

  公开（公告）日：2003-11-19

  New medicaments and compositions having an antiperspirant agent and an antimicrobial agent, and methods based thereof, for control, prevention, amelioration, or treatment of perspiration and topical microbial contamination or infection of skin of the hands, feet, groin, face and other areas of the body, along with reduction or control of symptoms and side effects of such perspiration and microbial contamination or infection, are disclosed. Such medicaments and compositions can be used for various cosmetic, medicinal or pharmaceutical purposes, including control of microbial growth on gloved hands, control of microbial contamination of hands, control of chronic irritation or infection of hands, feet, groin, head, or other areas of skin associated with athletic participation, control of facial acne or other similar conditions, as a cosmetic foundation, or for control of foot odor or excessive foot perspiration.

  本发明公开了具有止汗剂和抗菌剂的新型药物和组合物，以及基于它们的方法，用于控制、预防、改善或治疗手、脚、腹股沟、脸和身体其他部位皮肤的出汗和局部微生物污染或感染，以及减少或控制这种出汗和微生物污染或感染的症状和副作用。此类药剂和组合物可用于各种美容、医疗或制药目的，包括控制戴手套的手上的微生物生长，控制手部的微生物污染，控制手、脚、腹股沟、头部或其他与参加运动有关的皮肤部位的慢性刺激或感染，控制面部痤疮或其他类似情况，用作化妆品粉底，或控制脚臭或脚部出汗过多。
• Use of prodrugs for ocular intravitreous administration
  申请人：Novagali Pharma S.A.

  公开号：EP1864668A1

  公开（公告）日：2007-12-12

  Use of a composition comprising at least one prodrug of a steroid, preferably of a corticosteroid, for the preparation of an ophthalmic composition intended for the treatment of an ocular condition or disease of a human being or an animal.

  一种包含至少一种类固醇（最好是皮质类固醇）原药的组合物，用于制备治疗人或动物眼部状况或疾病的眼科组合物。