N-hydroxy-7-methyl-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-6-oxo-1-oxa-2,7-diazaspiro[4.4]non-2-ene-9-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-hydroxy-7-methyl-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-6-oxo-1-oxa-2,7-diazaspiro[4.4]non-2-ene-9-carboxamide
• 化学式: C₂₅H₂₄N₄O₅
• 分子量: 460.5
• InChiKey: JWSAGVUTOZNFLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme
  申请人：——

  公开号：US20040122005A1

  公开（公告）日：2004-06-24

  The present application describes novel isoxazoline of formula I or II: 1 or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, R 1 , R 2 , R 3 , R 4 , Z, U, X, Y, Z a , and n are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-&agr; converting enzyme (TACE), or a combination thereof.

  本申请描述了新型异噁唑烷式I或II的化合物：1或其药学上可接受的盐或前药形式，其中A、R1、R2、R3、R4、Z、U、X、Y、Za和n在本说明书中有定义，可用作基质金属蛋白酶（MMP）、TNF-α转化酶（TACE）或两者的抑制剂。
• US7125870B2
  申请人：——

  公开号：US7125870B2

  公开（公告）日：2006-10-24
• [EN] ISOXAZOLINE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-ALPHA CONVERTING ENZYME<br/>[FR] DERIVES D'ISOXAZOLINE COMME INHIBITEURS DE METALLOPROTEASES MATRICIELLES ET/OU D'ENZYME DE CONVERSION DE TNF- DOLLAR G(A)
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2004043349A2

  公开（公告）日：2004-05-27

  The present application describes novel isoxazoline of formula I or II: [TWO CHEMICAL STRUCTURES]or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, R1, R2, R3, R4, Z, U, X, Y, Za, and n are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-a converting enzyme (TACE), or a combination thereof.