N-[1-[4-[(5-aminopentylamino)methyl]piperidine-1-carbonyl]cyclopentyl]-2,4-dichloro-3-[(2,4-dimethylquinolin-8-yl)oxymethyl]benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[1-[4-[(5-aminopentylamino)methyl]piperidine-1-carbonyl]cyclopentyl]-2,4-dichloro-3-[(2,4-dimethylquinolin-8-yl)oxymethyl]benzenesulfonamide
• 化学式: C₃₅H₄₇Cl₂N₅O₄S
• 分子量: 704.7
• InChiKey: OSTKUSUHCKVXRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  47
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  135
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• BASIC NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM
  申请人：Menarini Ricerche S.p.A.

  公开号：EP1513531B1

  公开（公告）日：2009-10-21
• [EN] DIAGNOSIS, MONITORING, PROGNOSIS, PREVENTION AND TREATMENT OF ANEURYSMS<br/>[FR] DIAGNOSTIC, CONTRÔLE, PRONOSTIC, PRÉVENTION ET TRAITEMENT DES ANÉVRYSMES
  申请人：UNIV JAMES COOK

  公开号：WO2010127381A1

  公开（公告）日：2010-11-11

  The present invention relates generally to altering levels of components in the kallikrein-kinin system (KKS) to assist in preventing or treating aneurysms in an individual, and also to detecting the presence, determining the prognosis or monitoring the progression of an aneurysm by detecting aberrant expression of one or more genes in the kallikrein-kinin system (KKS). The invention also relates to methods for identifying agents that antagonise the KKS, and methods of producing agents comprising KKS antagonists for preventing or treating aneurysms.