反式-3-(甲基氨基)环丁烷-1-醇 | 1033710-19-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 反式-3-(甲基氨基)环丁烷-1-醇
• 中文别名: 3-(甲基氨基)环丁醇
• 英文名称: 3-(methylamino)cyclobutanol
• 英文别名: 3-(methylamino)cyclobutan-1-ol
• CAS: 1033710-19-8；1354952-94-5
• 化学式: C₅H₁₁NO
• mdl: MFCD20502026
• 分子量: 101.148
• InChiKey: DRLQGNZKHKBJFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  反式-3-(甲基氨基)环丁烷-1-醇 、 11-methyl-3,5-dioxo-1¹H-2,6-diaza-1(2,1)-benzo[d]imidazola-4(1,3)-benzenacycloundecaphane-1⁷-carboxylic acid 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以65 %的产率得到(E)-N-(3-hydroxycyclobutyl)-N,11-dimethyl-3,5-dioxo-1²,1³-dihydro-1¹H-2,6-diaza-1(2,1)-benzo[d]imidazola-4(1,3)-benzenacycloundecaphane-1⁷-carboxamide
  参考文献：
  名称：

  [EN] MACROCYCLIC TAK1 INHIBITORS
  [FR] INHIBITEURS MACROCYCLIQUES DE TAK1

  摘要：

  The invention provides a compound according to formula (I) or a tautomer thereof, wherein R1, R2, R3, W1, W2, W3, A, X and Y are as defined in the specification. The compounds are potent inhibitors of the serine/threonine kinase, TAK1. The present invention further provides: a pharmaceutical composition comprising a compound of formula (I) and at least one pharmaceutically acceptable excipient; a compound of formula (I) for use as a medicament (for example for the treatment or prophylaxis of a condition selected from cancer, inflammatory diseases, autoinflammatory diseases and autoimmune diseases); and a method of treating or preventing a disease or disorder comprising administering a pharmaceutically effective amount of a compound of formula (I) to a subject in need thereof.

  公开号：

  WO2023275199A1

文献信息

• [EN] BIARYL COMPOUNDS USEFUL AS IMMUNOMODULATORS<br/>[FR] COMPOSÉS BIARYLES UTILES EN TANT QU'IMMUNOMODULATEURS
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2018044963A1

  公开（公告）日：2018-03-08

  The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

  本公开涉及通常用作免疫调节剂的化合物。本文提供了包含这些化合物的组合物，以及它们的使用方法。该公开进一步涉及包含至少一种根据本公开的化合物的药物组合物，用于治疗各种疾病，包括癌症和传染病。