hexyl(4-methoxybenzyl)ether

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: hexyl(4-methoxybenzyl)ether
• 英文别名: 1-(Hexoxymethyl)-4-methoxybenzene
• 化学式: C₁₄H₂₂O₂
• 分子量: 222.327
• InChiKey: UQUASCZWBSIQLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  溶剂黄146 、 hexyl(4-methoxybenzyl)ether 反应 24.0h， 以93%的产率得到乙酸己酯
  参考文献：
  名称：

  Cleavage or Acetyl-de-alkylation of 4-Methoxybenzyl (MPM) Ethers Using Acetic Acid

  摘要：

  Aryl (4-methoxyphenyl)methyl (MPM) ethers are cleaved by heating with acetic acid for a few hours at 90-degrees-C, producing the corresponding phenols and (4-methoxyphenyl)methyl acetate. Under the same conditions alkyl MPM ethers are transformed directly into the corresponding alkyl acetates.

  DOI：

  10.1080/00397919408011711
• 作为产物：
  描述：

  三乙基(己氧基)硅烷 、 4-甲氧基苄醇 在 copper(ll) bromide 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以30%的产率得到hexyl(4-methoxybenzyl)ether
  参考文献：
  名称：

  Copper(II) bromide as efficient catalyst for silyl- to bisarylmethyl ethers interconversion (transprotection)

  摘要：

  Primary and secondary silylated alcohols are easily converted to bis(methoxyphenyl)methyl (BMPM) ethers in good yields using CuBr2 as catalyst in acetonitrile at room temperature. Various other protecting groups are compatible with this mild and convenient process. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.148

文献信息

• [EN] SYNTHESIS OF DELTA 12-PGJ3 AND RELATED COMPOUNDS<br/>[FR] SYNTHÈSE DE DELTA 12-PGJ3 ET COMPOSÉS ASSOCIÉS
  申请人：UNIV RICE WILLIAM M

  公开号：WO2015048268A1

  公开（公告）日：2015-04-02

  In one aspect, the present invention provides novel derivatives of Δ12-PGJ3 and modular synthetic pathways to obtaining Δ12-PGJ3 and derivatives thereof. In some aspects, the present derivatives of Δ12-PGJ3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.

  在一个方面，本发明提供了Δ12-PGJ3的新颖衍生物以及获取Δ12-PGJ3及其衍生物的模块化合成途径。在某些方面，目前的Δ12-PGJ3衍生物可用作化疗药物。本公开还描述了这些衍生物的组合物以及这些衍生物的使用方法。
• SYNTHESIS OF DELTA 12-PGJ3 AND RELATED COMPOUNDS
  申请人：WILLIAM MARSH RICE UNIVERSITY

  公开号：US20160318862A1

  公开（公告）日：2016-11-03

  In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.
• Copper(II) bromide as efficient catalyst for silyl- to bisarylmethyl ethers interconversion (transprotection)
  作者：Simon Specklin、Florian Gallier、Rofia Mezaache、Hassina Harkat、Yénimégué Albert Dembelé、Jean-Marc Weibel、Aurélien Blanc、Patrick Pale

  DOI：10.1016/j.tetlet.2011.08.148

  日期：2011.11

  Primary and secondary silylated alcohols are easily converted to bis(methoxyphenyl)methyl (BMPM) ethers in good yields using CuBr2 as catalyst in acetonitrile at room temperature. Various other protecting groups are compatible with this mild and convenient process. (C) 2011 Elsevier Ltd. All rights reserved.
• Cleavage or Acetyl-de-alkylation of 4-Methoxybenzyl (MPM) Ethers Using Acetic Acid
  作者：Kevin J. Hodgetts、Timothy W. Wallace

  DOI：10.1080/00397919408011711

  日期：1994.4

  Aryl (4-methoxyphenyl)methyl (MPM) ethers are cleaved by heating with acetic acid for a few hours at 90-degrees-C, producing the corresponding phenols and (4-methoxyphenyl)methyl acetate. Under the same conditions alkyl MPM ethers are transformed directly into the corresponding alkyl acetates.