1,2-bis-(D-gluco-2,3,4,5,6-pentahydroxy-hexylamino)-propane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2-bis-(D-gluco-2,3,4,5,6-pentahydroxy-hexylamino)-propane
• 英文别名: N.N'-Bis-(D-gluco-2.3.4.5.6-pentahydroxy-hexyl)-propylendiamin；1.2-Bis-D-glucamino-propan；1,2-Bis-(D-gluco-2,3,4,5,6-pentahydroxy-hexylamino)-propan；(2R,3R,4R,5S)-6-[2-[[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]amino]propylamino]hexane-1,2,3,4,5-pentol
• 化学式: C₁₅H₃₄N₂O₁₀
• 分子量: 402.442
• InChiKey: PUOKTLDDNCIOIF-MCTQMQHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.5
• 重原子数：
  27
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  226
• 氢给体数：
  12
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  葡萄糖 、 1,2-丙二胺 在 甲醇 作用下， 生成 1,2-bis-(D-gluco-2,3,4,5,6-pentahydroxy-hexylamino)-propane
  参考文献：
  名称：

  The Reaction of Glucose with Some Amines

  摘要：

  DOI：

  10.1021/ja01231a055

文献信息

• US6420344B1
  申请人：——

  公开号：US6420344B1

  公开（公告）日：2002-07-16
• US6531454B1
  申请人：——

  公开号：US6531454B1

  公开（公告）日：2003-03-11
• [EN] GLYCOSYLATED POLYAMINES<br/>[FR] POLYAMINES GLYCOSYLEES
  申请人：UNIV CALIFORNIA AT BERKELEY

  公开号：WO2000055166A1

  公开（公告）日：2000-09-21

  Glycosylated polyamines comprising of mono- or oligo-saccharides that are glycosidically linked to an aliphatic polyamine, and pharmaceutically acceptable salts, prodrugs and derivatives thereof are provided. An exemplary glycosylated polyamine has structure (A). Glycosylated polyamines, their pharmaceutically acceptable salts, prodrugs and derivatives are useful, for example, as anticancer compounds for the treatment of a variety of cancers. Methods for synthesis of glycosylated polyamines are disclosed. In addition, metal complexes of glycosylated polyamines, the preparation of such metal complexes, analytical methods using the metal complexes are provided. Methods for detecting equatorial and axial conformation of a group other than hydrogen at the C2 position of a saccharide molecule are also provided.
• The Reaction of Glucose with Some Amines
  作者：Eleanor Mitts、R. M. Hixon

  DOI：10.1021/ja01231a055

  日期：1944.3