1-cyclohexylamino-2-methyl-1-phenyl-2-propanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-cyclohexylamino-2-methyl-1-phenyl-2-propanol
• 英文别名: 1-(Cyclohexylamino)-2-methyl-1-phenylpropan-2-ol
• 化学式: C₁₆H₂₅NO
• 分子量: 247.381
• InChiKey: SIEUZWXOCGGVFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(苯基亚甲基)-环己胺 、 丙酮 在 萘 、 lithium 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以51%的产率得到N-苄基环己胺
  参考文献：
  名称：

  Naphthalene-catalysed lithiation of phenone imines in the presence of carbonyl compounds: preparation of 1,2-aminoalcohols

  摘要：

  The lithiation of different phenone imines 1 with an excess of lithium powder and a catalytic amount (8 mol %) of naphthalene in the presence of several carbonyl compounds 2 in tetrahydrofuran at temperatures ranging between -78 and 20-degrees-C leads, after hydrolysis with water, to the corresponding 1,2-aminoalcohols 3 in moderate yields.

  DOI：

  10.1016/s0040-4020(01)87249-5

文献信息

• Samarium diiodide/nickel diiodide an efficient system for homo and heterocoupling reactions of imines
  作者：Fouzia Machrouhi、Jean-Louis Namy

  DOI：10.1016/s0040-4039(98)02673-2

  日期：1999.2

  Samarium diiodide in the presence of a catalytic amount of nickel diiodide mediates a very fast dimerization of imines into vicinal diamines and the mixed coupling of imines and ketones to give β-amino alcohols.

  在催化量的二碘化镍存在下，二碘化可将亚胺非常快速地二聚为邻位二胺，并将亚胺和酮混合偶联，生成β-氨基醇。
• Naphthalene-catalysed lithiation of phenone imines in the presence of carbonyl compounds: preparation of 1,2-aminoalcohols
  作者：David Guijarro、Miguel Yus

  DOI：10.1016/s0040-4020(01)87249-5

  日期：1993.8

  The lithiation of different phenone imines 1 with an excess of lithium powder and a catalytic amount (8 mol %) of naphthalene in the presence of several carbonyl compounds 2 in tetrahydrofuran at temperatures ranging between -78 and 20-degrees-C leads, after hydrolysis with water, to the corresponding 1,2-aminoalcohols 3 in moderate yields.

表征谱图