3-<(cyclohexylamino)phenylmethyl>-3-pentanol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-<(cyclohexylamino)phenylmethyl>-3-pentanol
• 英文别名: 3-[(Cyclohexylamino)-phenylmethyl]pentan-3-ol
• 化学式: C₁₈H₂₉NO
• 分子量: 275.434
• InChiKey: YPIHNBKSAAROGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(苯基亚甲基)-环己胺 在 萘 、 lithium 、 3-戊酮 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以32%的产率得到3-<(cyclohexylamino)phenylmethyl>-3-pentanol
  参考文献：
  名称：

  Naphthalene-catalysed lithiation of phenone imines in the presence of carbonyl compounds: preparation of 1,2-aminoalcohols

  摘要：

  The lithiation of different phenone imines 1 with an excess of lithium powder and a catalytic amount (8 mol %) of naphthalene in the presence of several carbonyl compounds 2 in tetrahydrofuran at temperatures ranging between -78 and 20-degrees-C leads, after hydrolysis with water, to the corresponding 1,2-aminoalcohols 3 in moderate yields.

  DOI：

  10.1016/s0040-4020(01)87249-5

文献信息

• Naphthalene-catalysed lithiation of phenone imines in the presence of carbonyl compounds: preparation of 1,2-aminoalcohols
  作者：David Guijarro、Miguel Yus

  DOI：10.1016/s0040-4020(01)87249-5

  日期：1993.8

  The lithiation of different phenone imines 1 with an excess of lithium powder and a catalytic amount (8 mol %) of naphthalene in the presence of several carbonyl compounds 2 in tetrahydrofuran at temperatures ranging between -78 and 20-degrees-C leads, after hydrolysis with water, to the corresponding 1,2-aminoalcohols 3 in moderate yields.