mono-6-deoxy-6-amino-β-cyclodextrin

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: mono-6-deoxy-6-amino-β-cyclodextrin
• 英文别名: 6-amino-6-deoxy-β-cyclodextrin；β-cyclodextrin-NH2；6-Amino-6-deoxy-beta-cyclodextrin；5-(aminomethyl)-10,15,20,25,30,35-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol
• 化学式: C₄₂H₇₁NO₃₄
• 分子量: 1134.01
• InChiKey: OZBFLQITCMCIOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -15.3
• 重原子数：
  77
• 可旋转键数：
  7
• 环数：
  21.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  560
• 氢给体数：
  21
• 氢受体数：
  35

反应信息

• 作为反应物：
  描述：

  mono-6-deoxy-6-amino-β-cyclodextrin 、 二茂铁甲酸 以 not given 为溶剂， 生成
  参考文献：
  名称：

  A Biocompatible Surfactant with Folded Hydrophilic Head Group:  Enhancing the Stability of Self-Inclusion Complexes of Ferrocenyl in a β-Cyclodextrin Unit by Bond Rigidity

  摘要：

  This work reports a new biocompatible surfactant structure, of which the hydrophilic head group is composed of a folded, stable self-inclusion complex of a ferrocenyl substituted beta-cyclodextrin (beta CD). While multiple intra- or intermolecular complexes can exist for this amphiphile, the molecule folds into a unique intramolecular complex with well-defined conformation, in which part of the aliphatic chain and the ferrocene group are both included in the annular cavity of, CD. Study of different isosteric covalent linkages indicates that this folded structure is stable against displacement by the presence of other small guest molecules. Furthermore, in contrast to ferrocene-CD conjugates that are without the aliphatic chain, the presence of small guest molecules in solution does not influence at all the induced circular dichroism signal of this amphiphile, indicating a sterically congested, but stable, folded conformation of the inclusion complex. This new amphiphile is surface active and, more importantly, does not denature the membrane protein bacteriorhodopsin. Finally, because this surfactant forms self-assembled aggregates, this work introduces a folded structure into soft matters formed by amphiphiles in water.

  DOI：

  10.1021/ja064591q
• 作为产物：
  描述：

  6-mono-azido-β-cyclodextrin 在 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 以86%的产率得到mono-6-deoxy-6-amino-β-cyclodextrin
  参考文献：
  名称：

  Cyclodextrin Dimers as Cleavable Carriers of Photodynamic Sensitizers

  摘要：

  Several phthalocyanines carrying hydrophobic components have been synthesized and shown to bind to a group of cyclodextrin dimers with a carbon-carbon double bond in the linker. The complexes are soluble in water. On irradiation in the presence of oxygen, the singlet oxygen produced cleaves the olefinic linkers in the complexes, resulting in precipitation of the sensitizers. This process concentrates the sensitizers in the light beam, a process that has useful potential in photodynamic therapy.

  DOI：

  10.1021/ja011709o

文献信息

• MICROSPHERES CONTAINING THERAPEUTIC AGENTS AND RELATED METHODS OF USE
  申请人：Biosphere Medical, Inc.

  公开号：US20170231915A1

  公开（公告）日：2017-08-17

  Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.

  本文公开了微球、包括微球的组合物以及使用微球的方法。这些微球可以是基本球形的，可以包括单体的共聚物（如丙烯酸单体）和环糊精或其衍生物。这些微球还可以包括治疗剂，如基于铂的药物。
• Switching of a Macromolecular Helicity for Visual Distinction of Molecular Recognition Events
  作者：Eiji Yashima、Katsuhiro Maeda、Osamu Sato

  DOI：10.1021/ja016393z

  日期：2001.8.1
• COMPOSITIONS FOR SUNSCREEN COMPOUNDS AND METHODS THEREOF
  申请人：PMIDG, LLC

  公开号：EP4013374A1

  公开（公告）日：2022-06-22
• METHODS AND MEANS FOR THE MODIFICATION OF CELL SURFACES
  申请人：ACADEMISCH ZIEKENHUIS LEIDEN (ALSO ACTING UNDER THE NAME OF LEIDEN UNIVERSITY MEDICAL CENTER)

  公开号：US20180216060A1

  公开（公告）日：2018-08-02

  The invention relates to the utilization of specific cell surface biomarkers (preferably cell specific receptors) to generate a reversible layer-by-layer scaffold for the functionalization of cells. The cells of the present invention can be used in a wide variety of distinct applications, including cellular targeting, imaging, drug delivery, purification, cell sensing, diagnosis and waste stream/body fluid purification.
• [EN] COMPOSITIONS FOR SUNSCREEN COMPOUNDS AND METHODS THEREOF<br/>[FR] COMPOSITIONS DE COMPOSÉS D'ÉCRAN SOLAIRE ET PROCÉDÉS CORRESPONDANTS
  申请人：PMIDG LLC

  公开号：WO2021034834A1

  公开（公告）日：2021-02-25

  Disclosed herein are methods of making and using sunscreen compositions comprising at least one UV absorbing conjugate compound. The present disclosure comprises compositions comprising at least one UV absorbing conjugate compound that reflects and/or absorbs UV radiation, such as UV-A, UV-B and/or both UV-A and UV-B, that are not absorbed by, transmitted across and/or transported from the surface of the subject's body to the interior of the body or circulatory system of the subject's body.