4-nitro-1-phenyl-3-p-tolylbutan-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4-nitro-1-phenyl-3-p-tolylbutan-1-one
• 英文别名: (S)-4-nitro-3-phenyl-1-p-tolylbutan-1-one；(3S)-1-(4-methylphenyl)-4-nitro-3-phenylbutan-1-one
• 化学式: C₁₇H₁₇NO₃
• 分子量: 283.327
• InChiKey: YOXHGEZEIFRJCH-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-nitro-1-phenyl-3-p-tolylbutan-1-one 、 2-已烯醛 在 C₂₉H₃₀F₆N₄OS 作用下， 以 氯仿 为溶剂， 反应 64.0h， 以51%的产率得到((1R,2S,3S,4S,6S)-6-hydroxy-3-nitro-2-phenyl-4-propylcyclohexyl)-p-tolylmethanone
  参考文献：
  名称：

  Iterative Coupling of Two Different Enones by Nitromethane Using Bifunctional Thiourea Organocatalysts. Stereocontrolled Assembly of Cyclic and Acyclic Structures

  摘要：

  An organocatalytic iterative assembly line has been developed in which nitromethane was sequentially coupled with two different enones using a combination of pseudoenantiomeric cinchona-based thiourea catalysts. Application of unsaturated aldehydes and ketones in the second step of the iterative sequence allows the construction of cyclic synketols and acyclic compounds with multiple contiguous stereocenters. The combination of the multifunctional substrates and ambident electrophiles rendered some organocatalytic transformations possible that have not yet been realized in bifunctional noncovalent organocatalysis.

  DOI：

  10.1021/acs.joc.5b01474
• 作为产物：
  描述：

  β-硝基苯乙烯 、 3-oxo-3-p-toluoylpropanoic acid 在 C₄₀H₃₁F₆N₃O₂ 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 6.0h， 以83%的产率得到4-nitro-1-phenyl-3-p-tolylbutan-1-one
  参考文献：
  名称：

  双萘衍生的有机催化剂催化β-酮酸的对映选择性脱羧迈克尔加成至硝基烯烃

  摘要：

  已经开发了由手性双官能有机催化剂促进的催化对映选择性脱羧迈克尔加成反应，从而可以容易地合成具有优异对映选择性（最高97％ee）的相应γ-硝基酮。报告的方法代表了一种利用β-酮酸作为芳基甲基酮的合成等同物的有价值的方法。

  DOI：

  10.1016/j.tetlet.2012.09.100

文献信息

• Enantioselective Conjugate Addition of Both Aromatic Ketones and Acetone to Nitroolefins Catalyzed by Chiral Primary Amines Bearing Multiple Hydrogen-Bonding Donors
  作者：Zhong-Wen Sun、Fang-Zhi Peng、Ze-Qian Li、Li-Wei Zou、Shao-Xiong Zhang、Xiang Li、Zhi-Hui Shao

  DOI：10.1021/jo300011x

  日期：2012.4.20

  of chiral primary amine catalysts bearing multiple hydrogen-bonding donors have been designed and synthesized. The newly developed bifunctional organocatalysts efficiently catalyzed not only enantioselective conjugate addition of aromatic ketones to nitroolefins in good yields (up to 87%) with excellent enantioselectivities (97→99% ee) but also enantioselective conjugate addition of acetone to nitroolefins

  设计并合成了带有多个氢键供体的新型手性伯胺催化剂。新开发的双功能有机催化剂不仅能以良好的收率（97→99％ee）以良好的收率（高达87％）高效催化芳族酮对硝基烯烃的对映选择性共轭加成，而且还能以优异的收率（90催化丙酮）将丙酮对硝基选择性共轭加成。 –96％）具有高对映选择性（高达97％ee）。
• A general, highly enantioselective Michael addition of nitroalkanes to α,β-unsaturated enones catalyzed by 9-amino(9-deoxy)-epi-quinine: a remarkable additive effect
  作者：Siyang Liu、Qingqing Wang、Ling Ye、Zhichuan Shi、Zhigang Zhao、Xuejun Yang、Keyi Ding、Xuefeng Li

  DOI：10.1016/j.tet.2016.07.008

  日期：2016.8

  A particularly general protocol for the organocatalytic asymmetric Michael addition of nitroalkanes to α,β-unsaturated enones is reported. The Michael reaction proceeded smoothly and provided the desired adducts in moderate to excellent yields (55–99%) and good to excellent enantioselectivities (65–99% ee). The addition of readily available achiral base significantly enhanced the reactivity without

  报道了一种特别通用的方案，用于将硝基烷烃有机催化不对称迈克尔加成到α，β-不饱和烯酮上。迈克尔反应进展顺利，并以中等至优异的收率（55-99％）和良好至优异的对映选择性（65-99％ee）提供了所需的加合物。容易获得的非手性碱的加入显着增强了反应性，而没有损害对映选择性。
• Enantioselective Synthesis of Chiral Propargylic Alcohols Catalyzed by Bifunctional Zinc-Based Complexes
  作者：Xinhua Lu、Guanlei Xie、Tingyi Li、Xiaoming Qu、Jincheng Mao

  DOI：10.1080/00397911.2010.531367

  日期：2012.3.15

  Abstract This work demonstrates an efficient way to prepare chiral propargylic alcohols by asymmetric addition of terminal Zn-acetylide to aldehydes catalyzed by bifunctional zinc-based complexes. The corresponding products with moderate to good yields and enantioselectivities were obtained in the absence of moisture-sensitive Ti(O i Pr)4. GRAPHICAL ABSTRACT

  摘要 这项工作展示了一种通过将末端 Zn-乙炔化物不对称加成到由双功能锌基配合物催化的醛类制备手性炔丙醇的有效方法。在不存在对水分敏感的 Ti(O i Pr) 4 的情况下，获得了具有中等至良好产率和对映选择性的相应产品。图形概要
• Highly Enantioselective Michael Addition of Nitroalkanes to Chalcones Using Chiral Squaramides as Hydrogen Bonding Organocatalysts
  作者：Wen Yang、Da-Ming Du

  DOI：10.1021/ol102294g

  日期：2010.12.3

  squaramide-based organocatalysts were facilely synthesized and applied as hydrogen bonding organocatalysts in the enantioselective Michael addition of nitroalkanes to chalcones. These organocatalysts promoted the Michael addition with low catalyst loading under high temperature (80 °C), affording the desired R or S enantiomers of the products flexibly in high yields with excellent enantioselectivities (93−96%

  容易地合成了一系列基于方酰胺的有机催化剂，并将其用作氢键键合的有机催化剂，用于将硝基烷烃向查尔酮进行对映选择性迈克尔加成反应。这些有机催化剂促进迈克尔加成与高温下低的催化剂负载量（80℃），得到所期望的- [R或小号以高收率和优异的对映选择性（93-96％ee）的由有机催化剂的合适的选择灵活的产品的对映体。
• Asymmetric Michael Addition of Aromatic Ketones to Nitroolefins Catalyzed by Simple Chiral Bifunctional Primary Amine-Thioureas
  作者：Liangliang Wang、Xiaoying Xu、Jun Huang、Lin Peng、Qingchun Huang、Lixin Wang

  DOI：10.2174/157017810791514652

  日期：2010.7.1

  Simple chiral primary amine-thiourea catalysts derived from chiral 1,2-diphenylethylenediamine were found to catalyze direct Michael addition of aromatic ketones to nitroolefins with good enantioselectives (up to 86% ee) and excellent yields (up to 97%) for a broad range of substrates and successfully used in the preparation of (R)-Balcofen.

  简单的手性一级胺-硫脲催化剂来源于手性1,2-二苯乙烯二胺，已被发现能够以良好的手性选择性（最高可达86% ee）和优异的产率（最高可达97%）催化芳香酮与硝基烯烃的直接迈克尔加成，适用于广泛的底物，并成功用于(R)-Balcofen的制备。