N-[(2R,4S)-1-benzoyl-2-methyl-3,4-dihydro-2H-quinolin-4-yl]-2-methyl-N-phenylpropanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[(2R,4S)-1-benzoyl-2-methyl-3,4-dihydro-2H-quinolin-4-yl]-2-methyl-N-phenylpropanamide
• 化学式: C₂₇H₂₈N₂O₂
• 分子量: 412.5
• InChiKey: FTCWKSGDHXCEMZ-NLFFAJNJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES<br/>[FR] ANTAGONISTES DE RECEPTEUR DE LA PROSTAGLANDINE D2 POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES
  申请人：MILLENNIUM PHARM INC

  公开号：WO2005100321A1

  公开（公告）日：2005-10-27

  Disclosed herein are compounds represented by Structural Formula: (I) and (I-A). Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply 'CRTH2' for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.

  本文披露了由结构式(I)和(I-A)表示的化合物。还披露了利用这些化合物抑制称为趋化剂受体同源分子表达在Th2上的G蛋白偶联受体，简称为'CRTH2'，用于治疗炎症性疾病。结构式(I)和(I-A)中的变量在此处被定义。
• PGD2 receptor antagonists for the treatment of inflammatory diseases
  申请人：Ghosh Shomir

  公开号：US20050256158A1

  公开（公告）日：2005-11-17

  Disclosed herein are compounds represented by Structural Formula (I) and (I-A): Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.

  本文揭示了由结构式（I）和（I-A）表示的化合物：还披露了利用这些化合物抑制称为Th2表达的G蛋白偶联受体的化学引诱受体同源分子，简称“CRTH2”，用于治疗炎症性疾病。结构式（I）和（I-A）中的变量在此处被定义。
• Quinoline derivatives as CRTH2 antagonists
  申请人：——

  公开号：US20040132772A1

  公开（公告）日：2004-07-08

  The invention relates to compounds of formula (I) 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined in the description, their use as medicament, pharmaceutical compositions containing them and processes for their preparation.

  本发明涉及式(I)1的化合物，其中R1、R2、R3、R4、R5、R6、R7和R8如描述中所定义，它们的用途为药物，含有它们的制药组合物以及它们的制备方法。
• Quinoline Derivatives as CRTH2 Antagonists
  申请人：Ali Awad M. Mohamed

  公开号：US20070197587A1

  公开（公告）日：2007-08-23

  The invention relates to compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined in the description, their use as medicament, pharmaceutical compositions containing them and processes for their preparation.

  该发明涉及式(I)的化合物，其中R1、R2、R3、R4、R5、R6、R7和R8如描述中所定义，它们作为药物的用途、含有它们的制药组合物以及它们的制备方法。
• Asthma and allergic inflammation modulators
  申请人：Inman D. Wayne

  公开号：US20050038070A1

  公开（公告）日：2005-02-17

  Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are tetrahydroquinoline derivatives.

  本发明提供了可用于治疗炎症和免疫相关疾病和病症的化合物、药物组合物和方法。特别是，本发明提供了调节特应性疾病、炎症和癌症相关蛋白质功能和/或表达的化合物。所述化合物为四氢喹啉衍生物。