D(+)-α-hydroxy-isocaproaldehyde

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D(+)-α-hydroxy-isocaproaldehyde
• 英文别名: D(+)-α-Hydroxy-isocapronaldehyd；(2R)-2-hydroxy-4-methylpentanal
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: JXHLRWGQMIUGOS-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  D(+)-α-hydroxy-isocaproaldehyde 、 3-羟基-2-氧代丙酸 在 transketolase 作用下， 以5%的产率得到(3S,4R)-1,3,4-trihydroxy-6-methylheptan-2-one
  参考文献：
  名称：

  Amino acid precursors for the detection of transketolase activity in Escherichia coli auxotrophs

  摘要：

  Probes were developed for the in vivo detection of transketolase activity by the use of a complementation assay in Escherichia coli auxotrophs They combine the D-threo ketose moiety recognised by transketolase and the side chain of leucine or methionine. These compounds were donor substrates of yeast transketolase leading to the release of the corresponding alpha-hydroxyaldehydes which could be converted in E. coli by a cascade of reactions into leucine or methionine required for cellular growth. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.111
• 作为产物：
  描述：

  (-)(R)-2-methyl-hepten-(5)-ol-(4) 在 溶剂黄146 作用下， 生成 D(+)-α-hydroxy-isocaproaldehyde
  参考文献：
  名称：

  Bartlett; Kuna; Levene, Journal of Biological Chemistry, 1937, vol. 118, p. 515

  摘要：

  DOI：

文献信息

• Bartlett; Kuna; Levene, Journal of Biological Chemistry, 1937, vol. 118, p. 515
  作者：Bartlett、Kuna、Levene

  DOI：——

  日期：——
• Amino acid precursors for the detection of transketolase activity in Escherichia coli auxotrophs
  作者：Grégory Simon、Madeleine Bouzon、Franck Charmantray、Virgil Hélaine、Bertrand Légeret、Philippe Marlière、Laurence Hecquet

  DOI：10.1016/j.bmcl.2009.04.111

  日期：2009.7

  Probes were developed for the in vivo detection of transketolase activity by the use of a complementation assay in Escherichia coli auxotrophs They combine the D-threo ketose moiety recognised by transketolase and the side chain of leucine or methionine. These compounds were donor substrates of yeast transketolase leading to the release of the corresponding alpha-hydroxyaldehydes which could be converted in E. coli by a cascade of reactions into leucine or methionine required for cellular growth. (C) 2009 Elsevier Ltd. All rights reserved.