2-[4-(4-dimethylaminophenyl)-1,3-butadienyl]-4,5-dimethyloxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[4-(4-dimethylaminophenyl)-1,3-butadienyl]-4,5-dimethyloxazole
• 英文别名: 4-[(1E,3E)-4-(4,5-dimethyl-1,3-oxazol-2-yl)buta-1,3-dienyl]-N,N-dimethylaniline
• 化学式: C₁₇H₂₀N₂O
• 分子量: 268.359
• InChiKey: GAINQTNUNOSZOJ-KQQUZDAGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,5-dimethyl-2-[(diethoxyphosphinyl)-methyl]-oxazole 、 4-异丙基肉桂醛 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 以23.5%的产率得到2-[4-(4-dimethylaminophenyl)-1,3-butadienyl]-4,5-dimethyloxazole
  参考文献：
  名称：

  Probe for diseases with amyloid accumulation, amyloid-staining agent, remedy and preventive for diseases with amyloid accumulation and diagnostic probe and staining agent for neurofibrillary change

  摘要：

  本发明提供了对淀粉样蛋白β具有高亲和力的化合物，用于诊断淀粉样蛋白β在其中积累的疾病，用于特异染色淀粉样蛋白β的试剂，以及用于治疗和/或预防淀粉样蛋白β在其中积累的疾病。本发明还提供了用于神经原纤维缠结的探针和染色试剂。

  公开号：

  US20060018825A1

文献信息

• PROBE FOR DISEASES WITH AMYLOID ACCUMULATION, AMYLOID-STAINING AGENT, REMEDY AND PREVENTIVE FOR DISEASES WITH AMYLOID ACCUMULATION AND DIAGNOSTIC PROBE AND STAINING AGENT FOR NEUROFIBRILLARY CHANGE
  申请人：BF Research Institute, Inc.

  公开号：EP1655287A1

  公开（公告）日：2006-05-10

  The present invention provides compounds having high affinity for amyloid β-protein which are for the diagnosis of diseases in which amyloid β-protein accumulates, for agents for specifically staining amyloid β-protein, and for the treatment and/or prophylaxis of diseases in which amyloid β-protein accumulates. The present invention also provides probes and staining agents for neurofibrillary tangles.

  本发明提供了对淀粉样β蛋白具有高亲和力的化合物，这些化合物可用于诊断淀粉样β蛋白聚集的疾病，用于特异性染色淀粉样β蛋白的制剂，以及用于治疗和/或预防淀粉样β蛋白聚集的疾病。本发明还提供了神经纤维缠结的探针和染色剂。
• Probe for diseases with amyloid accumulation, amyloid-staining agent, remedy and preventive for diseases with amyloid accumulation and diagnostic probe and staining agent for neurofibrillary change
  申请人：Kudo Yukitsuka

  公开号：US20060018825A1

  公开（公告）日：2006-01-26

  The present invention provides compounds having high affinity for amyloid β-protein which are for the diagnosis of diseases in which amyloid β-protein accumulates, for agents for specifically staining amyloid β-protein, and for the treatment and/or prophylaxis of diseases in which amyloid β-protein accumulates. The present invention also provides probes and staining agents for neurofibrillary tangles.

  本发明提供了对淀粉样蛋白β具有高亲和力的化合物，用于诊断淀粉样蛋白β在其中积累的疾病，用于特异染色淀粉样蛋白β的试剂，以及用于治疗和/或预防淀粉样蛋白β在其中积累的疾病。本发明还提供了用于神经原纤维缠结的探针和染色试剂。