2-hydroxy-3-tridecylbenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-3-tridecylbenzoic acid
• 英文别名: 2-Hydroxy-3-tridecylbenzoic acid
• 化学式: C₂₀H₃₂O₃
• 分子量: 320.472
• InChiKey: SGEOCQUXLUVNOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  23
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯甲酸,二羟基- 在 吡啶 、 palladium 10% on activated carbon 、 水 、 氢气 、 potassium carbonate 、 三氟乙酸 、 三氟乙酸酐 、 potassium hydroxide 作用下， 以 二氯甲烷 、 二甲基亚砜 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 58.5h， 生成 2-hydroxy-3-tridecylbenzoic acid
  参考文献：
  名称：

  SUMO化抑制剂银杏酸衍生物的合成与评价

  摘要：

  SUMOylation 已成为一种重要的翻译后修饰，已被证明可调节与各种信号通路相关的蛋白质活性，因此，它已成为重要的治疗靶点。虽然几种天然产物已被证明可以抑制参与 SUMOylation 过程的酶，但在开发更具选择性和效力的 SUMOylation 抑制剂方面进展甚微。银杏酸是最早发现的可抑制 SUMO E1 酶的天然产物之一。尽管它用于机械研究 SUMO 化过程，银杏酸也调节其他途径。在这封信中，介绍了银杏酸作为 SUMO 化抑制剂的初步构效关系。

  DOI：

  10.1021/acsmedchemlett.0c00353

文献信息

• Compositions containing oils having a specific gravity higher than the specific gravity of water
  申请人：Lapidot Noa

  公开号：US20050037087A1

  公开（公告）日：2005-02-17

  The invention relates to pharmaceutical or cosmetic compositions preferably in the form of microcapsules or microparticles which include at least one active ingredient and an oil or a mixture of oils wherein the oil or mixture of oils alone or in combination with the active ingredient have a specific gravity higher than the specific gravity of water. The invention further relates to a process for preparing said compositions.

  本发明涉及制药或化妆品组合物，优选为微胶囊或微粒形式，包括至少一种活性成分和油或油混合物，其中油或油混合物单独或与活性成分组合具有比水的比重高的特性。本发明还涉及制备该组合物的方法。
• NOVEL COMPOUNDS
  申请人：Schlifke-Poschalko Alexander

  公开号：US20120282201A1

  公开（公告）日：2012-11-08

  The invention relates to novel polyglycerol based UV-filters as well as to topical compositions comprising such novel polyglycerol based UV-filters. Furthermore, the invention relates to the use of such novel polyglycerol based UV-filters to enhance the solubility of butyl methoxydibenzoylmethane or bis-ethylhexyloxyphenol methoxyphenyl triazine in cosmetic oils.

  该发明涉及新型基于聚甘油的紫外线过滤剂，以及包含这种新型基于聚甘油的紫外线过滤剂的局部组合物。此外，该发明还涉及使用这种新型基于聚甘油的紫外线过滤剂来增强丁基甲氧基二苯甲酰甲烷或双-乙基己氧基苯甲酰甲烷在化妆油中的溶解度。
• COMPOSITIONS CONTAINING OILS HAVING A SPECIFIC GRAVITY HIGHER THAN THE SPECIFIC GRAVITY OF WATER
  申请人：LAPIDOT Noa

  公开号：US20120321685A1

  公开（公告）日：2012-12-20

  The invention relates to pharmaceutical or cosmetic compositions preferably in the form of microcapsules or microparticles which include at least one active ingredient and an oil or a mixture of oils wherein the oil or mixture of oils alone or in combination with the active ingredient have a specific gravity higher than the specific gravity of water. The invention further relates to a process for preparing said compositions.

  本发明涉及制药或化妆品组合物，优选为微胶囊或微粒形式，其中包括至少一种活性成分和一种油或混合油，其中油或混合油单独或与活性成分结合具有比水的比重大的比重。本发明还涉及制备所述组合物的方法。
• 2-PHENYL- 1,2,3- BENZOTRIAZOLES FOR UV RADIATION ABSORBANCE
  申请人：Schlifkeposchalko Alexander

  公开号：US20130142737A1

  公开（公告）日：2013-06-06

  The present invention relates to novel benzotriazoles and to novel topical compositions comprising these benzotriazoles. Furthermore, the invention relates to the use of the novel benzotriazoles as photostabilizer and solubiliser for dibenzoyl-methane derivatives such as Butyl Methoxydibenzoylmethane. In one aspect the invention relates to novel benzotriazoles of formula (Ia) wherein R 2 is hydrogen; C 1-30 alkyl; C 1-5 alkoxy; C 1-5 alkoxycarbonyl; C 5-7 cycloalkyl; C 6-10 aryl or aralkyl; R 3 is hydrogen; C 1-5 alkyl; C 1-5 alkoxy or halogen, preferably hydrogen or Cl; R 4 is hydrogen or C 1-5 alkyl; R 5 is C 1-30 alkyl or C 5-10 cycloalkyl.

  本发明涉及新型苯并三唑和含有这些苯并三唑的新型局部制剂。此外，本发明涉及将新型苯并三唑用作光稳定剂和溶解剂，以用于二苯甲酰甲烷衍生物，例如丁基甲氧基二苯甲酰甲烷。在一个方面，本发明涉及式（Ia）的新型苯并三唑，其中R2为氢；C1-30烷基；C1-5烷氧基；C1-5烷氧羰基；C5-7环烷基；C6-10芳基或芳基烷基；R3为氢；C1-5烷基；C1-5烷氧基或卤素，优选氢或氯；R4为氢或C1-5烷基；R5为C1-30烷基或C5-10环烷基。
• Cosmetic composition with retinol unsaturated fatty acid esters
  申请人：UNILEVER PLC

  公开号：EP0807429A1

  公开（公告）日：1997-11-19

  A method and composition are provided for enhancing skin radiance and treating chronoaging conditions including wrinkles and dermatological disorders including acne, follicular and lesional papules, actinic keratoses, oily skin and rosacea comprising a safe and effective amount of an unsaturated C18-C30 fatty acid ester of retinol and a safe and effective amount of a cosmetically acceptable carrier, the composition being stable for at least four weeks at 43°C. An unsaturated C18-C30 fatty acid ester of retinol is the active component which is applied to the skin in a cosmetically acceptable carrier. The most preferred unsaturated retinol fatty acid ester is retinyl linoleate. The composition is stable and remains active for at least four weeks at 43°C.

  本发明提供了一种方法和组合物，用于增强皮肤光泽和治疗慢性衰老状况，包括皱纹和皮肤病，包括痤疮、毛囊性和皮损性丘疹、光化性角化病、油性皮肤和红斑痤疮，该组合物由安全有效量的视黄醇不饱和 C18-C30 脂肪酸酯和安全有效量的化妆品可接受载体组成，该组合物在 43°C 下稳定至少四周。视黄醇的不饱和 C18-C30 脂肪酸酯是活性成分，与化妆品可接受的载体一起涂抹在皮肤上。最理想的不饱和视黄醇脂肪酸酯是亚油酸视黄醇酯。该组合物稳定，在 43°C 温度下可保持至少四周的活性。