钙离子载体 V | 160563-01-9

• 物质功能分类: 分析化学 - 分析试剂 - 常用分析试剂
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 钙离子载体 V
• 中文别名: 实电解质K23E1；钙离子载体V
• 英文名称: 10,19-bis[(octadecylcarbamoyl)methoxyacetyl]-1,4,7,13,16-pentaoxa-10,19-diazacycloheneicosane
• 英文别名: Calcium ionophore V；N-octadecyl-2-[2-[19-[2-[2-(octadecylamino)-2-oxoethoxy]acetyl]-1,4,7,13,16-pentaoxa-10,19-diazacyclohenicos-10-yl]-2-oxoethoxy]acetamide
• CAS: 160563-01-9
• 化学式: C₅₈H₁₁₂N₄O₁₁
• 分子量: 1041.55
• InChiKey: LKKJODPUVIMZGC-UHFFFAOYSA-N

物化性质

• 沸点：
  1052.7±65.0 °C(Predicted)
• 密度：
  0.985±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  14.4
• 重原子数：
  73
• 可旋转键数：
  42
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  163
• 氢给体数：
  2
• 氢受体数：
  11

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  十八胺 在 吡啶 、 盐酸 、 phosphinic chloride 、 三乙胺 作用下， 反应 0.25h， 生成 钙离子载体 V
  参考文献：
  名称：

  Design and Synthesis of Calcium and Magnesium Ionophores Based on Double-Armed Diazacrown Ether Compounds and Their Application to an Ion Sensing Component for an Ion-Selective Electrode

  摘要：

  The double-armed diazacrown ethers, which have a base diazacrown ether ring with two diamide-type side chains, were designed and synthesized on the basis of the proposed molecular model for the novel neutral Ca2+ and Mg2+ ionophores. The potentiometric ion-selective electrodes were prepared with over 20 kinds of systematically synthesized diazacrown ether derivatives. The relationship between the molecular structures of the ionophores and the ion selectivities was fully discussed. The electrodes based on the 21- and 18-membered diazacrown ether derivatives possessing a glycolic diamide and malonic diamide in their side chains (K23E1 and K22B5) exhibited excellent Ca2+ and Mg2+ selectivities, respectively. The ion-selectivity features of the novel Ca2+ and Mg2+ ionophores supply important structural information about the design of host molecules for alkaline earth metal cations.

  DOI：

  10.1021/ac00098a016

文献信息

• METHODS OF ACUTE RESTORATION OF VASCULAR COMPLIANCE
  申请人：Alumend, LLC

  公开号：EP3763371A1

  公开（公告）日：2021-01-13

  Disclosed herein is a compound comprising a 4-amino-1,8-naphthalimide for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty . Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

  本发明公开了一种包含 4-氨基-1,8-萘二甲酰亚胺的化合物，可用于涂抹在血管上的组合物中，其中该化合物可软化和/或破坏钙化斑块的结晶基质，以及快速恢复血管治疗部位的血管顺应性，同时在血管成形术期间保持管腔增大。还公开了包括应用所公开组合物的治疗方法。还公开了斑块软化化合物。
• Compositions and methods of using the compositions for plaque softening
  申请人：ALUMEND, LLC

  公开号：US10131635B2

  公开（公告）日：2018-11-20

  Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

  本文公开了一种用于血管的组合物中的化合物，其中的化合物可软化和/或破坏钙化斑块的结晶基质。还公开了包括应用所公开组合物的治疗方法。还公开了斑块软化化合物。
• Systems and methods for detecting an optical change indicating the presence of an analyte
  申请人：Case Western Reserve University

  公开号：US10393665B2

  公开（公告）日：2019-08-27

  One aspect of the present disclosure relates to an analyte sensor device. The analyte sensor device can include an optode layer that undergoes an optical change in the presence of an analyte. The analyte sensor device can also include a selectively-permeable membrane encapsulating the optode layer to form a stable membrane that that minimizes fouling of the analyte sensor device. The analyte sensor device can also include a plurality of microparticles that suppress a background physical interference on a detection of the optical change of the optode layer.

  本公开的一个方面涉及一种分析物传感器装置。分析物传感器装置可以包括一个光电极层，在分析物存在的情况下，光电极层会发生光学变化。分析物传感器装置还可以包括封装光电极层的选择性渗透膜，以形成稳定的膜，最大限度地减少分析物传感器装置的堵塞。分析物传感器装置还可以包括多个微颗粒，以抑制背景物理干扰对光极层光学变化的检测。
• Extensible, multimodal sensor fusion platform for remote, proximal terrain sensing
  申请人：Teralytic, Inc.

  公开号：US10866208B2

  公开（公告）日：2020-12-15

  A sensor assembly includes a housing and multiple sensor array segments. A first sensor array segment includes an antenna. A second sensor array segment has a soil temperature sensor, an electrical conductivity (EC) sensor, a moisture sensor, an ion-sensitive field effect transistor (ISFET) nitrate sensor for detecting nitrates in adjacent soil, an ISFET phosphate sensor for detecting phosphates in adjacent soil, an ISFET potassium sensor for detecting potassium in adjacent soil, and an ISFET pH sensor for detecting pH in adjacent soil, and a reference electrode electrically coupled to the first sensor array segment and to the second sensor array segment. The first sensor array segment and the reference electrode can be disposed on opposite sides of the second sensor array segment.

  传感器组件包括一个外壳和多个传感器阵列部分。第一个传感器阵列部分包括一个天线。第二传感器阵列段有一个土壤温度传感器、一个电导率（EC）传感器、一个湿度传感器、一个用于检测邻近土壤中硝酸盐含量的离子敏感场效应晶体管（ISFET）硝酸盐传感器、一个用于检测邻近土壤中磷酸盐含量的离子敏感场效应晶体管磷酸盐传感器、一个用于检测邻近土壤中钾含量的离子敏感场效应晶体管钾传感器和一个用于检测邻近土壤中 pH 值的离子敏感场效应晶体管 pH 传感器，以及一个与第一传感器阵列段和第二传感器阵列段电耦合的参比电极。第一传感器阵列区段和参比电极可布置在第二传感器阵列区段的相对两侧。
• Methods of acute restoration of vascular compliance
  申请人：Alumend, LLC

  公开号：US10959995B2

  公开（公告）日：2021-03-30

  Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.

  本文公开了一种用于血管的组合物中的化合物，其中的化合物能软化和/或破坏钙化斑块的结晶基质，并能迅速恢复血管治疗部位的血管顺应性，同时在血管成形术期间保持管腔增大。还公开了包括应用所公开组合物的治疗方法。还公开了斑块软化化合物。