ethyl-9-chloro-2-methyl-5-(3,4-dimethoxy phenyl)-5H-chromene[3,4-c]pyridine-1-carboxylate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: ethyl-9-chloro-2-methyl-5-(3,4-dimethoxy phenyl)-5H-chromene[3,4-c]pyridine-1-carboxylate
• 英文别名: ethyl 9-chloro-5-(3,4-dimethoxyphenyl)-2-methyl-5H-chromeno[3,4-c]pyridine-1-carboxylate
• 化学式: C₂₄H₂₂ClNO₅
• 分子量: 439.895
• InChiKey: ZLOLMVMJDOHAGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  6-Chlor-3',4'-dimethoxy-flavanon 在 三氯氧磷 作用下， 以 溶剂黄146 为溶剂， 反应 48.0h， 生成 ethyl-9-chloro-2-methyl-5-(3,4-dimethoxy phenyl)-5H-chromene[3,4-c]pyridine-1-carboxylate
  参考文献：
  名称：

  A FACILE SYNTHESIS OF ETHYL-2-METHYL-5-ARYL-5H-CHROMENO-[3,4-c]PYRIDINE-1-CARBOXYLATES

  摘要：

  Flav-4-ones on reaction with DMF/POCl3 gave 4-chloro-2-aryl-2H-chromene-3-carbaldehydes which on reaction with ethyl-3-aminocrotonate give under Hantszch reaction conditions ethyl-2-methyl-5-aryl-5H-chromeno[3,4-c]pyridine-1-carboxylates in good yields.

  DOI：

  10.1081/scc-100105383

文献信息

• A FACILE SYNTHESIS OF ETHYL-2-METHYL-5-ARYL-5H-CHROMENO-[3,4-c]PYRIDINE-1-CARBOXYLATES
  作者：M. Venkati、G. L. David Krupadanam

  DOI：10.1081/scc-100105383

  日期：2001.1.1

  Flav-4-ones on reaction with DMF/POCl3 gave 4-chloro-2-aryl-2H-chromene-3-carbaldehydes which on reaction with ethyl-3-aminocrotonate give under Hantszch reaction conditions ethyl-2-methyl-5-aryl-5H-chromeno[3,4-c]pyridine-1-carboxylates in good yields.