5-methyl-5H-pyrazino[2,3-b]indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-methyl-5H-pyrazino[2,3-b]indole
• 英文别名: 5-Methylpyrazino[2,3-b]indole
• 化学式: C₁₁H₉N₃
• 分子量: 183.213
• InChiKey: LNRRPNSTGNXFCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙二胺 、 ethyl 3-{[(trifluoromethyl)sulfonyl]oxy}-1-methyl-1H-2-indolecarboxylate 在 palladium diacetate 、 三苯基膦 三乙胺 作用下， 反应 7.0h， 以40%的产率得到5-methyl-5H-pyrazino[2,3-b]indole
  参考文献：
  名称：

  Reactions of 3-([(trifluoromethyl)sulfonyl]oxy)-1H-indole derivatives with diamines and carbon nucleophiles. Synthesis of 6H-indolo[2,3-b]quinoxaline derivatives

  摘要：

  Indolic triflate reacted with 1,2-diamines to afford pyrazino[2,3-b]indole or indolo[2,3-b] quinoxaline. Carbon nucleophiles such as malonate derivatives also reacted with indolic triflate in absence of palladium catalyst to afford 2-(3-oxo-2,3 -dihydro-1H-2-indolyliden) malonate derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00650-4

文献信息

• SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME
  申请人：BlinkBio, Inc.

  公开号：US20170202970A1

  公开（公告）日：2017-07-20

  Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.

  本文描述了基于硅的共轭物，能够将一个或多个有效载荷基团传递到靶细胞或组织。考虑到的共轭物可能包括一个硅-杂原子核心，一个或多个可选的催化基团，一个定位基团，允许共轭物在靶细胞或组织内积累，一个或多个有效载荷基团（例如，治疗剂或成像剂），以及与硅-杂原子核心共价结合的两个或更多个不干扰基团。
• Asymmetric Hosts With Triaryl Silane Side Chains
  申请人：Dyatkin Alexey

  公开号：US20130293094A1

  公开（公告）日：2013-11-07

  Novel asymmetric host compounds containing an electron-transport moiety, a hole-transport moiety, an aromatic spacer, and a triaryl silane group are provided. These compounds are useful materials that can be incorporated into OLED devices.

  提供含有电子传输基团、空穴传输基团、芳香族间隔基和三芳基硅烷基团的新型非对称宿主化合物。这些化合物是有用的材料，可被纳入OLED设备中。
• MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE AND ORGANIC ELECTROLUMINESCENCE DEVICE UTILIZING THE SAME
  申请人：Iwakuma Toshihiro

  公开号：US20090017330A1

  公开（公告）日：2009-01-15

  A material for organic electroluminescence devices of the invention which is for use in combination with at least one phosphorescent metal complex has a specific heterocyclic structure. The material for organic electroluminescence devices is used as a host material or a hole transporting material. An organic electroluminescence device having an anode, a cathode and an organic thin film layer having one or more layers which is interposed between the anode and cathode, in which at least one layer of the organic thin film layer contains the material for organic electroluminescence devices, has a high emitting efficiency, causes little pixel defects, is excellent in heat resistance, and shows a long lifetime.

  该发明的有机电致发光器件材料，用于与至少一种磷光金属配合使用，具有特定的杂环结构。该有机电致发光器件材料用作主体材料或空穴传输材料。具有阳极、阴极和有机薄膜层的有机电致发光器件，该有机薄膜层具有至少一层，位于阳极和阴极之间，其中有机薄膜层的至少一层含有该有机电致发光器件材料，具有高发光效率，几乎没有像素缺陷，具有优异的耐热性，并显示出长寿命。
• SUBSTITUTED OLIGOAZACARBAZOLES FOR LIGHT EMITTING DIODES
  申请人：Dyatkin Alexey

  公开号：US20120256169A1

  公开（公告）日：2012-10-11

  Novel compounds containing substituted oligoazacarbazole chains are provided. These compounds are useful in organic light emitting devices, in particular as hosts in the emissive layer of such devices.

  提供了含有取代寡聚氮杂咔唑链的新型化合物。这些化合物在有机发光器件中非常有用，特别是作为这些器件发射层中的宿主。
• ORGANIC COMPOUND, CHARGE-TRANSPORTING MATERIAL, COMPOSITION FOR CHARGE-TRANSPORTING MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE
  申请人：IIDA Koichiro

  公开号：US20090284134A1

  公开（公告）日：2009-11-19

  An organic compound having excellent heat resistance, an excellent amorphous nature, an excellent ability to transport charges, highly excited singlet and triplet states, and excellent solubility in an organic solvent is an organic compound represented by Formula (I): wherein Ar 1 represents an optionally-substituted aromatic hydrocarbon group, an optionally-substituted aromatic heterocyclic group, or an optionally-substituted alkyl group; Ar 2 represents an optionally-substituted aromatic hydrocarbon group or an optionally-substituted aromatic heterocyclic group; R 1 and R 2 each represent a hydrogen atom or a substituent, and R 1 and R 2 may be bonded to each other to form a ring; and Q is represented by Formula (I-1) or (I-2): wherein Ar 3 to Ar 5 each represent an optionally-substituted aromatic hydrocarbon group or an optionally-substituted aromatic heterocyclic group, and Ar 3 and Ar 4 may be bonded to each other to form a ring.

  具有优异热稳定性、优异非晶性、优异电荷传输能力、高度激发单重态和三重态状态、以及在有机溶剂中优异溶解性的有机化合物，可以用公式（I）表示，其中Ar1代表可选取代的芳香烃基、可选取代的芳香杂环基或可选取代的烷基；Ar2代表可选取代的芳香烃基或可选取代的芳香杂环基；R1和R2分别代表氢原子或取代基，R1和R2可相互连接形成环；Q由公式（I-1）或（I-2）表示，其中Ar3至Ar5分别代表可选取代的芳香烃基或可选取代的芳香杂环基，Ar3和Ar4可相互连接形成环。